# Eukaryotic translation initiation factor 4 gamma 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115725](https://www.wikidata.org/wiki/Q21115725)  
**Source**: https://4ort.xyz/entity/eukaryotic-translation-initiation-factor-4-gamma-1-q21115725


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q04637)
3. Q20641742
4. [Human Eukaryotic Translation Initiation Factor 4G (eIF4G) Possesses Two Separate and Independent Binding Sites for eIF4A](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04637&geneProductId=UniProtKB:Q04637)
5. [A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04637&geneProductId=UniProtKB:Q04637)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04637&geneProductId=UniProtKB:Q04637)
7. [Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
8. [The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
9. [AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
10. [Embryonic poly(A)-binding protein stimulates translation in germ cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
11. [Multiple portions of poly(A)-binding protein stimulate translation in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
12. [Interaction of eIF4G with poly(A)-binding protein stimulates translation and is critical for Xenopus oocyte maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
13. [Up-regulation of PDCD4 in senescent human diploid fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
14. [Cell stress modulates the function of splicing regulatory protein RBM4 in translation control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
15. [Two zebrafish eIF4E family members are differentially expressed and functionally divergent](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
16. [Human INT6/eIF3e is required for nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
17. [Human Eukaryotic Initiation Factor 4G (eIF4G) Protein Binds to eIF3c, -d, and -e to Promote mRNA Recruitment to the Ribosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
18. [eIF4GI Facilitates the MicroRNA-Mediated Gene Silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
19. [Structural Analysis of the DAP5 MIF4G Domain and Its Interaction with eIF4A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
20. [DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
21. [Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
22. [Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
23. [Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
24. [Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
25. [Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
26. [eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
27. [Translational repression precedes and is required for ZAP-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
28. [Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
29. [p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
30. [eIF4G is required for the pioneer round of translation in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
31. [A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
32. [Characterization of mammalian eIF4E-family members](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
33. [Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
34. [Proteomics of herpes simplex virus infected cell protein 27: association with translation initiation factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
35. [Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
36. [Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
37. [Human Translation Initiation Factor eIF4G1 Possesses a Low-Affinity ATP Binding Site Facing the ATP-Binding Cleft of eIF4A in the eIF4G/eIF4A Complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04637&geneProductId=UniProtKB:Q04637)
38. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04637&geneProductId=UniProtKB:Q04637)
39. [Human Eukaryotic Initiation Factor 4G (eIF4G) Protein Binds to eIF3c, -d, and -e to Promote mRNA Recruitment to the Ribosome](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04637&geneProductId=UniProtKB:Q04637)
40. [Human Translation Initiation Factor eIF4G1 Possesses a Low-Affinity ATP Binding Site Facing the ATP-Binding Cleft of eIF4A in the eIF4G/eIF4A Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
41. [A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
42. [Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
43. [eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
44. [The EIF4G1 gene and Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
45. [Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
46. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04637&geneProductId=UniProtKB:Q04637)
47. [Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
48. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
49. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)
50. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04637)