Eukaryotic translation initiation factor 2-alpha kinase pek-1 CELE_F46C3.1
type: Thing
description: protein found in Caenorhabditis elegans
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: California State Route 56
additional property: PropertyValue
  property ID: P361
  value: Quinoprotein alcohol dehydrogenase-like superfamily
additional property: PropertyValue
  property ID: P361
  value: Protein kinase-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: WD40/YVTN repeat-like-containing domain superfamily
additional property: PropertyValue
  property ID: P527
  value: Pyrrolo-quinoline quinone beta-propeller repeat
additional property: PropertyValue
  property ID: P527
  value: protein kinase domain
additional property: PropertyValue
  property ID: P527
  value: protein kinase, ATP binding site
additional property: PropertyValue
  property ID: P637
  value: NP_509912
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: protein kinase activity
additional property: PropertyValue
  property ID: P680
  value: protein serine/threonine kinase activity
additional property: PropertyValue
  property ID: P681
  value: endoplasmic reticulum
additional property: PropertyValue
  property ID: P681
  value: endoplasmic reticulum membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P682
  value: positive regulation of protein phosphorylation
additional property: PropertyValue
  property ID: P682
  value: nematode larval development
additional property: PropertyValue
  property ID: P682
  value: regulation of translation
additional property: PropertyValue
  property ID: P702
  value: pek-1
additional property: PropertyValue
  property ID: P703
  value: Caenorhabditis elegans
additional property: PropertyValue
  property ID: P705
  value: F46C3.1
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 14
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 14
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q19192
    source count: 1
    confidence: 0.2
    value label: California State Route 56
  P361:
    value: Q24777844
    source count: 1
    confidence: 0.2
    value label: Quinoprotein alcohol dehydrogenase-like superfamily
  P361:
    value: Q24726164
    source count: 1
    confidence: 0.2
    value label: Protein kinase-like domain superfamily
  P361:
    value: Q24784804
    source count: 1
    confidence: 0.2
    value label: WD40/YVTN repeat-like-containing domain superfamily
  P361:
    value: Q83138186
    source count: 1
    confidence: 0.2
    value label: Protein kinase domain, protein family
  P361:
    value: Q95350774
    source count: 1
    confidence: 0.2
    value label: Pyrrolo-quinoline quinone beta-propeller repeat, protein family
  P527:
    value: Q24722795
    source count: 1
    confidence: 0.2
    value label: Pyrrolo-quinoline quinone beta-propeller repeat
  P527:
    value: Q24768234
    source count: 1
    confidence: 0.2
    value label: protein kinase domain
  P527:
    value: Q24769051
    source count: 1
    confidence: 0.2
    value label: protein kinase, ATP binding site
  P527:
    value: Q24726991
    source count: 1
    confidence: 0.2
    value label: Pyrrolo-quinoline quinone repeat
  P527:
    value: Q24787419
    source count: 1
    confidence: 0.2
    value label: serine/threonine-protein kinase, active site
  P637:
    value: NP_509912
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14820641
    source count: 1
    confidence: 0.2
    value label: protein kinase activity
  P680:
    value: Q14326094
    source count: 2
    confidence: 0.4
    value label: protein serine/threonine kinase activity
  P680:
    value: Q14905679
    source count: 1
    confidence: 0.2
    value label: eukaryotic translation initiation factor 2alpha kinase activity
  P680:
    value: Q14817981
    source count: 2
    confidence: 0.4
    value label: ATP binding
  P681:
    value: Q79927
    source count: 1
    confidence: 0.2
    value label: endoplasmic reticulum
  P681:
    value: Q14329032
    source count: 2
    confidence: 0.4
    value label: endoplasmic reticulum membrane
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q14327652
    source count: 1
    confidence: 0.2
    value label: integral component of membrane
  P682:
    value: Q14819846
    source count: 3
    confidence: 0.6
    value label: positive regulation of protein phosphorylation
  P682:
    value: Q22298503
    source count: 1
    confidence: 0.2
    value label: nematode larval development

value: Q14863717
source count: 1
confidence: 0.2
value label: regulation of translation

value: Q7251493
source count: 2
confidence: 0.4
value label: protein phosphorylation

value: Q14864261
source count: 1
confidence: 0.2
value label: response to unfolded protein

value: Q29686294
source count: 1
confidence: 0.2
value label: pek-1

value: Q91703
source count: 1
confidence: 0.2
value label: Caenorhabditis elegans

value: F46C3.1
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-01

source: GOA
stated in qid: Q28018111
retrieved: 2018-07-16

source: Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
stated in qid: Q24292104
retrieved: 2018-09-10

source: Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress
stated in qid: Q22253195
retrieved: 2018-07-16

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2018-01-01

source: Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress
stated in qid: Q22253195
retrieved: 2018-01-01

source: Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
stated in qid: Q24292104
retrieved: 2018-01-01

source: Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2
stated in qid: Q27333486
retrieved: 2018-01-01

source: Protein Misfolding Induces Hypoxic Preconditioning via a Subset of the Unfolded Protein Response Machinery
stated in qid: Q34190184
retrieved: 2018-01-01

source: A novel interaction between aging and ER overload in a protein conformational dementia
stated in qid: Q42089588
retrieved: 2018-01-01

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2018-12-05

source: Q20641742
stated in qid: Q20641742
retrieved: 2018-12-14

source: ensembl Release 96
stated in qid: Q63170780

wikidata id: Q29801549
domain: protein
level: standard
html url: https://4ort.xyz/entity/eukaryotic-translation-initiation-factor-2-alpha-kinase-pek-1-cele-f46c3-1
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facts url summary: https://4ort.xyz/entity/eukaryotic-translation-initiation-factor-2-alpha-kinase-pek-1-cele-f46c3-1/facts.json
facts url standard: https://4ort.xyz/entity/eukaryotic-translation-initiation-factor-2-alpha-kinase-pek-1-cele-f46c3-1/facts.json
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data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-07T03:55:27.902634Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:48:31.873729+00:00Z