# Eukaryotic translation initiation factor 2 alpha kinase 3

> mammalian protein found in Mus musculus

**Wikidata**: [Q21984224](https://www.wikidata.org/wiki/Q21984224)  
**Source**: https://4ort.xyz/entity/eukaryotic-translation-initiation-factor-2-alpha-kinase-3-q21984224


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Z2B5)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
5. [Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5)
7. [Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5)
8. [Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
9. [Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
10. [Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
11. [Hepatitis C Virus Envelope Protein E1 Binds PERK and Represses the Unfolded Protein Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
12. [Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
13. [Mfn2 modulates the UPR and mitochondrial function via repression of PERK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
14. [Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5)
15. [Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2B5&geneProductId=UniProtKB:Q9Z2B5)
16. [The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
17. [Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
18. [Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
20. [Neurotrophic signaling in normal and degenerating rodent retinas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
21. [Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
22. [The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
23. [PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
24. [PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
25. [Perk is essential for translational regulation and cell survival during the unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
26. [PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
27. [Regulated translation initiation controls stress-induced gene expression in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
28. [The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
29. [TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
30. [Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
31. [Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
32. [PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
33. [Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
34. [Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
35. [ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2B5)
36. ensembl Release 106