# Eukaryotic translation initiation factor 2 alpha kinase 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21172758](https://www.wikidata.org/wiki/Q21172758)  
**Source**: https://4ort.xyz/entity/eukaryotic-translation-initiation-factor-2-alpha-kinase-3-q21172758


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9NZJ5)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
5. [Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5)
7. [The endoplasmic reticulum stress response in aging and age-related diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
8. [TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
9. [Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
10. [TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
11. [Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
12. [PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
13. [H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
14. [p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5)
15. [Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5)
16. [Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5)
17. [Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5)
18. [Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
20. [Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
21. [p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
22. [Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
23. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5)
24. [The unfolded protein response: integrating stress signals through the stress sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
25. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
26. [The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
27. [Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
28. [Ursolic acid induces ER stress response to activate ASK1–JNK signaling and induce apoptosis in human bladder cancer T24 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
29. [Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5)
30. ensembl Release 95