# Eukaryotic translation initiation factor 2 alpha kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7251483](https://www.wikidata.org/wiki/Q7251483)  
**Source**: https://4ort.xyz/entity/eukaryotic-translation-initiation-factor-2-alpha-kinase-2-q7251483


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P19525)
4. [UniProt](http://www.uniprot.org/uniprot/P19525.txt?187)
5. [Swiss-Prot](http://www.uniprot.org/uniprot/P19525.txt?version=189)
6. Q20641742
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
8. [Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525)
10. [Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525)
11. [Nck-1 interacts with PKR and modulates its activation by dsRNA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525)
12. [Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525)
13. [Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
14. [TRAF family proteins link PKR with NF-kappa B activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
15. [The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
16. [Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
17. [Nck-1 interacts with PKR and modulates its activation by dsRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
18. [Novel role of PKR in inflammasome activation and HMGB1 release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
19. [Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
20. [Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
21. [The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
22. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
23. [Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
24. [The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
25. [Homologous Regions of the α Subunit of Eukaryotic Translational Initiation Factor 2 (eIF2α) and the Vaccinia Virus K3L Gene Product Interact with the Same Domain within the dsRNA‐Activated Protein Kinase (PKR)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
26. [Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
27. [Detection of a Novel Unglycosylated Form of Hepatitis C Virus E2 Envelope Protein That Is Located in the Cytosol and Interacts with PKR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
28. [Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
29. [Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
30. [New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
31. [Antiviral action of the tumor suppressor ARF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
32. [Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
33. [Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
34. [Molecular basis for PKR activation by PACT or dsRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
35. [Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
36. [Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
37. [Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
38. [Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
39. [The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525)
40. [p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525)
41. [The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
42. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525)
43. [Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
44. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
45. [Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
46. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
47. [p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
48. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19525&geneProductId=UniProtKB:P19525)
49. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)
50. [PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19525)