# estrogen receptor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5401858](https://www.wikidata.org/wiki/Q5401858)  
**Source**: https://4ort.xyz/entity/estrogen-receptor-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200598)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL68055)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL786)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL487)
7. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P03372)
8. Q20641742
9. [Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
11. [The affinity and activity of the multiple hormone response element in the proximal promoter of the human oxytocin gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P03372&geneProductId=UniProtKB:P03372)
12. [The affinity and activity of the multiple hormone response element in the proximal promoter of the human oxytocin gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
13. [Roles of estrogen receptor alpha and androgen receptor in the regulation of neuronal nitric oxide synthase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P03372&geneProductId=UniProtKB:P03372)
15. [Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbeta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
16. [Interaction of the tumor metastasis suppressor nonmetastatic protein 23 homologue H1 and estrogen receptor alpha alters estrogen-responsive gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
17. [Oestrogen receptor facilitates the formation of preinitiation complex assembly: involvement of the general transcription factor TFIIB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
18. [Functional genomics identifies a mechanism for estrogen activation of the retinoic acid receptor alpha1 gene in breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
19. [Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
20. [Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P03372&geneProductId=UniProtKB:P03372)
21. [Wnt/beta-catenin and estrogen signaling converge in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
22. [ERRF is essential for Estrogen-Estrogen Receptor alpha signaling pathway in ER positive breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
23. [Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
24. [Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
25. [Functional regulation of oestrogen receptor pathway by the dynein light chain 1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
26. [The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
27. [Repression of estrogen receptor beta function by putative tumor suppressor DBC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
28. [Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
29. [The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
30. [BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
31. [The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
32. [Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
33. [Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
34. [Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
35. [Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
36. [Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
37. [Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
38. [Human ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
39. [Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
40. [Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
41. [Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
42. [MS-KIF18A, a kinesin, is associated with estrogen receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
43. [Modulation of ER alpha transcriptional activity by the orphan nuclear receptor ERR beta and evidence for differential effects of long- and short-form splice variants.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
44. [An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
45. [WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
46. [ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
47. [H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERα ligand dependency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
48. [TRIM24 links a non-canonical histone signature to breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
49. [Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)
50. [Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03372)