# ERCC excision repair 2, TFIIH core complex helicase subunit

> mammalian protein found in humans

**Wikidata**: [Q426168](https://www.wikidata.org/wiki/Q426168)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/ERCC2)  
**Source**: https://4ort.xyz/entity/ercc-excision-repair-2-tfiih-core-complex-helicase-subunit


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P18074)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
5. [Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
6. [A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
7. [Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074)
9. [Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
10. [IOP1 Protein Is an External Component of the Human Cytosolic Iron-Sulfur Cluster Assembly (CIA) Machinery and Functions in the MMS19 Protein-dependent CIA Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
11. [A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
12. [Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
13. [MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
14. [p53 modulation of TFIIH–associated nucleotide excision repair activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
15. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
16. [Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
17. [The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
18. [Near-atomic resolution visualization of human transcription promoter opening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
19. [Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
21. [A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074)
22. [Human cyclin-dependent kinase-activating kinase exists in three distinct complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074)
23. [MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074)
24. [Human cyclin-dependent kinase-activating kinase exists in three distinct complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
25. [DNA nucleotide excision repair-dependent signaling to checkpoint activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
26. [Trichothiodystrophy, a transcription syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
27. [A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074)
28. [Genetic susceptibility of newborn daughters to oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074)
29. [Molecular cloning and biological characterization of a human gene, ERCC2, that corrects the nucleotide excision repair defect in CHO UV5 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
30. [Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074)
31. [Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
32. [The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
33. [ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
34. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P18074&geneProductId=UniProtKB:P18074)
35. [Genetic susceptibility of newborn daughters to oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18074)
36. Ensembl Release 99
37. Identifiers.org
38. UMLS 2023
39. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)