# Erb-b2 receptor tyrosine kinase 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21104817](https://www.wikidata.org/wiki/Q21104817)  
**Source**: https://4ort.xyz/entity/erb-b2-receptor-tyrosine-kinase-4


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q15303)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
6. [Mechanism of activation and inhibition of the HER4/ErbB4 kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
7. [HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303)
8. [Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tryosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
9. [Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
10. [WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
11. [An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
12. [Interactions of ErbB4 and Kap1 Connect the Growth Factor and DNA Damage Response Pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
13. [Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
14. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
15. [The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
16. [Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
17. [Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
18. [HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
19. [Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
20. [Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
21. [An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
22. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
23. [Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303)
25. [Mechanism of activation and inhibition of the HER4/ErbB4 kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303)
27. [HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
28. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
29. [Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
30. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303)
31. [Segregation of receptor and ligand regulates activation of epithelial growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
32. [The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
33. [The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
34. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
35. [Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303)
36. [Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
37. [Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
38. [Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
39. [Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303)
40. [A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303)
41. [The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
42. [Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15303&geneProductId=UniProtKB:Q15303)
43. [Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15303)
44. Ensembl Release 99
45. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)
46. UMLS 2023
47. Transporter Classification database