# Erb-b2 receptor tyrosine kinase 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21104746](https://www.wikidata.org/wiki/Q21104746)  
**Source**: https://4ort.xyz/entity/erb-b2-receptor-tyrosine-kinase-3


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545154)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2408045)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P21860)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
7. [Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
8. [Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
9. [A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
10. [Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
11. [Ebp1 isoforms distinctively regulate cell survival and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
12. [Interaction of Necl-4/CADM4 with ErbB3 and integrin α6 β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
13. [NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
14. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
15. [Pharmacological targeting of the pseudokinase Her3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
16. [Binding of Neu Differentiation Factor with the Extracellular Domain of Her2 and Her3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
17. [HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
18. [Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
19. [A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
20. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
21. [Growth stimulation of non-small cell lung cancer cell lines by antibody against epidermal growth factor receptor promoting formation of ErbB2/ErbB3 heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
22. [Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
23. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
24. [Oncogenic ERBB3 mutations in human cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
25. [HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
26. [Spontaneous and pronase-induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
27. [Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
28. [Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
29. [An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
30. [Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
31. [Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
32. [Parallel visualization of multiple protein complexes in individual cells in tumor tissue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
33. [Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
34. [Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
35. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
36. [PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
37. [Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
38. [Spatial structure and dimer--monomer equilibrium of the ErbB3 transmembrane domain in DPC micelles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
39. [Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860)
40. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860)
41. [Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860)
42. [The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
43. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860)
44. [Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860)
45. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
46. [Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
47. [Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
48. [Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860)
49. [Segregation of receptor and ligand regulates activation of epithelial growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21860)
50. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21860&geneProductId=UniProtKB:P21860)