# Erb-b2 receptor tyrosine kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q415271](https://www.wikidata.org/wiki/Q415271)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/HER2)  
**Source**: https://4ort.xyz/entity/erb-b2-receptor-tyrosine-kinase-2


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2364649)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2110732)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2007641)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3989868)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1645462)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545396)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL483321)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL598797)
11. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545154)
12. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2408045)
13. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2103842)
14. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3544983)
15. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P04626)
16. Q20641742
17. Freebase Data Dumps. 2013
18. [Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
20. [Identification of a region within the ErbB2/HER2 intracellular domain that is necessary for ligand-independent association](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
21. [Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
22. [Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
23. [Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
24. [Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
25. [Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
26. [Copine-III interacts with ErbB2 and promotes tumor cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
27. [Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
28. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
29. [IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
30. [Binding of Neu Differentiation Factor with the Extracellular Domain of Her2 and Her3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
31. [HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
32. [Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
33. [ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
34. [Tyrosine Phosphorylation of c-ErbB-2 Is Regulated by the Cellular Form of Prostatic Acid Phosphatase in Human Prostate Cancer Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
35. [Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
36. [Cyanidin-3-Glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
37. [A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
38. [Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
39. [Brk is coamplified with ErbB2 to promote proliferation in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
40. [Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
41. [Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
42. [Growth stimulation of non-small cell lung cancer cell lines by antibody against epidermal growth factor receptor promoting formation of ErbB2/ErbB3 heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
43. [Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
44. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
45. [Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
46. [Oncogenic ERBB3 mutations in human cancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
47. [HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
48. [Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
49. [Spontaneous and pronase-induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)
50. [Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04626)