# Epithelial cell transforming 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115853](https://www.wikidata.org/wiki/Q21115853)  
**Source**: https://4ort.xyz/entity/epithelial-cell-transforming-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9H8V3)
3. Q20641742
4. [The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
5. [Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
7. [Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
8. [Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
9. [Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
10. [Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
11. [Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
12. [Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
13. [The armadillo protein p0071 regulates Rho signalling during cytokinesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
14. [MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
15. [An ECT2-centralspindlin complex regulates the localization and function of RhoA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
16. [Dissecting the role of Rho-mediated signaling in contractile ring formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
17. [Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
18. [Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
19. [Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
20. [Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
21. [Phosphoregulation of MgcRacGAP in mitosis involves Aurora B and Cdk1 protein kinases and the PP2A phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
22. [Plk4 is required for cytokinesis and maintenance of chromosomal stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
23. [Downregulation of cough by exercise and voluntary hyperpnea](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
24. [The Nuclear Guanine Nucleotide Exchange Factors Ect2 and Net1 Regulate RhoB-Mediated Cell Death after DNA Damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3)
25. Ensembl Release 99