# epidermal growth factor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q424374](https://www.wikidata.org/wiki/Q424374)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Epidermal_growth_factor)  
**Source**: https://4ort.xyz/entity/epidermal-growth-factor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P01133)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
6. [Nerve Growth Factor Regulation of m4 Muscarinic Receptor mRNA Stability but Not Gene Transcription Requires Mitogen-activated Protein Kinase Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
7. [Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
9. [EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
10. [Ligand-induced structural transitions in ErbB receptor extracellular domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
11. [Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
12. [Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
13. [Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
14. [Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
15. [Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
16. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
17. [Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
18. [Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01133&geneProductId=UniProtKB:P01133)
20. [Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01133&geneProductId=UniProtKB:P01133)
21. [Nerve Growth Factor Regulation of m4 Muscarinic Receptor mRNA Stability but Not Gene Transcription Requires Mitogen-activated Protein Kinase Activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01133&geneProductId=UniProtKB:P01133)
22. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01133&geneProductId=UniProtKB:P01133)
23. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01133&geneProductId=UniProtKB:P01133)
24. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01133&geneProductId=UniProtKB:P01133)
25. [Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01133&geneProductId=UniProtKB:P01133)
26. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01133&geneProductId=UniProtKB:P01133)
27. [Human colostrum: identification of minor proteins in the aqueous phase by proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01133&geneProductId=UniProtKB:P01133)
28. [Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
29. [Human colostrum: identification of minor proteins in the aqueous phase by proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
30. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
31. [Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
32. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
33. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
34. [Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
35. [Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
36. [Expression of Q227L-galphas in MCF-7 human breast cancer cells inhibits tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01133&geneProductId=UniProtKB:P01133)
37. [ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
38. [Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
39. [The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
40. [Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
41. [Epidermal growth factor’s activation of Ras is inhibited by four cardiac hormones](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
42. [Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
43. [Epidermal growth factor receptor regulates β-catenin location, stability, and transcriptional activity in oral cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
44. [The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01133)
45. Ensembl Release 99
46. Identifiers.org
47. UMLS 2023
48. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)