# epidermal growth factor receptor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q424401](https://www.wikidata.org/wiki/Q424401)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Epidermal_growth_factor_receptor)  
**Source**: https://4ort.xyz/entity/epidermal-growth-factor-receptor


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL4650319)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2087361)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2110732)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3353410)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3663929)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1645462)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545396)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2029988)
11. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL598797)
12. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL258940)
13. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL49120)
14. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL607707)
15. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1963502)
16. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545154)
17. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2408045)
18. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545235)
19. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2103842)
20. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3544983)
21. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P00533)
22. Q20641742
23. Freebase Data Dumps. 2013
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
25. [Activation of epidermal growth factor receptor signals induction of nitric oxide synthase-2 in human optic nerve head astrocytes in glaucomatous optic neuropathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533)
27. [Transforming growth factor {beta} (TGF-{beta})-Smad target gene protein tyrosine phosphatase receptor type kappa is required for TGF-{beta} function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
28. [Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
29. [Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
30. [Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
31. [Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
32. [Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
33. [ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
34. [Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
35. [EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
36. [Flow cytometric in situ proximity ligation analyses of protein interactions and post-translational modification of the epidermal growth factor receptor family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
37. [In Situ Analysis of Mutant EGFRs Prevalent in Glioblastoma Multiforme Reveals Aberrant Dimerization, Activation, and Differential Response to Anti-EGFR Targeted Therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
38. [Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
39. [Parallel visualization of multiple protein complexes in individual cells in tumor tissue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
40. [A Proximity Ligation Assay Using Transiently Transfected, Epitope-Tagged Proteins: Application for in Situ Detection of Dimerized Receptor Tyrosine Kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
41. [Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
42. [PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
43. [EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
44. [An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
45. [A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
46. [Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
47. [Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
48. [Conformational coupling across the plasma membrane in activation of the EGF receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
49. [Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)
50. [Comparative analysis of fluorescence resonance energy transfer (FRET) and proximity ligation assay (PLA)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533)