# Epidermal growth factor receptor pathway substrate 8

> mammalian protein found in Mus musculus

**Wikidata**: [Q21498751](https://www.wikidata.org/wiki/Q21498751)  
**Source**: https://4ort.xyz/entity/epidermal-growth-factor-receptor-pathway-substrate-8-q21498751


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q08509)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
5. [An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin–polymerizing machine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
6. [Regulation of Stereocilia Length by Myosin XVa and Whirlin Depends on the Actin-Regulatory Protein Eps8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
7. [Eps8 controls actin-based motility by capping the barbed ends of actin filaments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
8. [Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8–IRSp53 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
9. [Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
10. [SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
11. [Increased Ethanol Resistance and Consumption in Eps8 Knockout Mice Correlates with Altered Actin Dynamics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
12. [The Insulin Receptor Substrate of 53 kDa (IRSp53) Limits Hippocampal Synaptic Plasticity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
13. [Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
14. [Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived Neurotrophic Factor (BDNF)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
15. [IRSp53/Eps8 Complex Is Important for Positive Regulation of Rac and Cancer Cell Motility/Invasiveness](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08509&geneProductId=UniProtKB:Q08509)
17. [An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin–polymerizing machine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08509&geneProductId=UniProtKB:Q08509)
18. [Eps8 controls actin-based motility by capping the barbed ends of actin filaments](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08509&geneProductId=UniProtKB:Q08509)
19. [Molecular Basis for the Dual Function of Eps8 on Actin Dynamics: Bundling and Capping](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08509&geneProductId=UniProtKB:Q08509)
20. [Molecular Basis for the Dual Function of Eps8 on Actin Dynamics: Bundling and Capping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
22. [Increased Ethanol Resistance and Consumption in Eps8 Knockout Mice Correlates with Altered Actin Dynamics](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08509&geneProductId=UniProtKB:Q08509)
23. [EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
24. [A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
25. [Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
26. [Conditional deletion of Eps8 reduces hippocampal synaptic plasticity and impairs cognitive function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
27. [The Signaling Adaptor Eps8 Is an Essential Actin Capping Protein for Dendritic Cell Migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
28. [miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08509)
29. ensembl Release 106