Ephrin A1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P20827
additional property: PropertyValue
  property ID: P361
  value: ephrins
additional property: PropertyValue
  property ID: P361
  value: Cupredoxin
additional property: PropertyValue
  property ID: P361
  value: membrane protein
additional property: PropertyValue
  property ID: P486
  value: D036382
additional property: PropertyValue
  property ID: P527
  value: Ephrin receptor-binding domain
additional property: PropertyValue
  property ID: P527
  value: Ephrin, conserved site
additional property: PropertyValue
  property ID: P527
  value: Ephrin-A ectodomain
additional property: PropertyValue
  property ID: P637
  value: NP_004419
additional property: PropertyValue
  property ID: P637
  value: NP_872626
additional property: PropertyValue
  property ID: P638
  value: 3HEI
additional property: PropertyValue
  property ID: P638
  value: 3MBW
additional property: PropertyValue
  property ID: P638
  value: 3CZU
additional property: PropertyValue
  property ID: P672
  value: D12.644.276.500.100
additional property: PropertyValue
  property ID: P672
  value: D12.776.395.550.448.300
additional property: PropertyValue
  property ID: P672
  value: D12.776.467.500.100
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: signaling receptor binding
additional property: PropertyValue
  property ID: P680
  value: ephrin receptor binding
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P681
  value: integral component of plasma membrane
additional property: PropertyValue
  property ID: P682
  value: regulation of cell adhesion mediated by integrin
additional property: PropertyValue
  property ID: P682
  value: ephrin receptor signaling pathway
additional property: PropertyValue
  property ID: P682
  value: aortic valve morphogenesis
additional property: PropertyValue
  property ID: P702
  value: EFNA1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000357391
additional property: PropertyValue
  property ID: P705
  value: ENSP00000357392
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 22
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 22
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P20827
    source count: 1
    confidence: 0.2
  P361:
    value: Q24787399
    source count: 1
    confidence: 0.2
    value label: ephrins
  P361:
    value: Q24772015
    source count: 1
    confidence: 0.2
    value label: Cupredoxin
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q83167634
    source count: 1
    confidence: 0.2
    value label: Ephrin-A ectodomain, protein family
  P361:
    value: Q95351415
    source count: 1
    confidence: 0.2
    value label: Ephrin, conserved site, protein family
  P486:
    value: D036382
    source count: 0
    confidence: 0.0
  P527:
    value: Q24776308
    source count: 1
    confidence: 0.2
    value label: Ephrin receptor-binding domain
  P527:
    value: Q24741892
    source count: 1
    confidence: 0.2
    value label: Ephrin, conserved site
  P527:
    value: Q28544286
    source count: 1
    confidence: 0.2
    value label: Ephrin-A ectodomain
  P637:
    value: NP_004419
    source count: 1
    confidence: 0.2
  P637:
    value: NP_872626
    source count: 1
    confidence: 0.2
  P638:
    value: 3HEI
    source count: 1
    confidence: 0.2
  P638:
    value: 3MBW
    source count: 1
    confidence: 0.2
  P638:
    value: 3CZU
    source count: 1
    confidence: 0.2
  P672:
    value: D12.644.276.500.100
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.395.550.448.300
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.467.500.100
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.543.287.100
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.543.484.500.300
    source count: 0
    confidence: 0.0

value: Q167149
source count: 4
confidence: 0.8
value label: protein binding

value: Q14819233
source count: 1
confidence: 0.2
value label: signaling receptor binding

value: Q14897681
source count: 3
confidence: 0.6
value label: ephrin receptor binding

value: Q14897681
source count: 4
confidence: 0.8
value label: ephrin receptor binding

value: Q14349455
source count: 2
confidence: 0.4
value label: membrane

value: Q29548
source count: 2
confidence: 0.4
value label: plasma membrane

value: Q14859540
source count: 1
confidence: 0.2
value label: integral component of plasma membrane

value: Q14864741
source count: 1
confidence: 0.2
value label: anchored component of membrane

value: Q903634
source count: 1
confidence: 0.2
value label: extracellular exosome

value: Q14905484
source count: 1
confidence: 0.2
value label: regulation of cell adhesion mediated by integrin

value: Q14905487
source count: 4
confidence: 0.8
value label: ephrin receptor signaling pathway

value: Q14906410
source count: 2
confidence: 0.4
value label: aortic valve morphogenesis

value: Q14758911
source count: 1
confidence: 0.2
value label: cell-cell signaling

value: Q14633878
source count: 2
confidence: 0.4
value label: negative regulation of transcription by RNA polymerase II

value: Q17916054
source count: 1
confidence: 0.2
value label: EFNA1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000357391
source count: 1
confidence: 0.2

value: ENSP00000357392
source count: 1
confidence: 0.2

value: C0246321
source count: 1
confidence: 0.2

source: EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt
stated in qid: Q24310260
retrieved: 2019-04-08

source: Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex
stated in qid: Q24338237
retrieved: 2019-04-08

source: NMR structure of a heterodimeric SAM:SAM complex: characterization and manipulation of EphA2 binding reveal new cellular functions of SHIP2.
stated in qid: Q36451527
retrieved: 2019-04-08

source: Architecture of Eph receptor clusters
stated in qid: Q27661948
retrieved: 2019-04-08

source: The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3
stated in qid: Q24318045
retrieved: 2019-04-08

source: A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein
stated in qid: Q24596894
retrieved: 2017-05-23

source: Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis
stated in qid: Q24298470
retrieved: 2017-05-23

source: GOA
stated in qid: Q28018111
retrieved: 2017-05-23

source: A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein
stated in qid: Q24596894
retrieved: 2019-04-08

source: Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis
stated in qid: Q24298470
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3
stated in qid: Q24318045
retrieved: 2017-05-23

source: Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
stated in qid: Q24313258
retrieved: 2017-05-23

source: Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway
stated in qid: Q31814817
retrieved: 2019-04-08

source: Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
stated in qid: Q22011187
retrieved: 2019-04-08

source: Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
stated in qid: Q22011187
retrieved: 2017-05-23

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: UMLS 2023
stated in qid: Q118645236
retrieved: 2023-05-25

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21156333
domain: protein
level: standard
html url: https://4ort.xyz/entity/ephrin-a1
markdown url: https://4ort.xyz/entity/ephrin-a1.md
facts url summary: https://4ort.xyz/entity/ephrin-a1/facts.json
facts url standard: https://4ort.xyz/entity/ephrin-a1/facts.json
facts url full: https://4ort.xyz/entity/ephrin-a1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-23T12:00:43.793020Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:58:50.900290+00:00Z