# Enhancer of zeste 2 polycomb repressive complex 2 subunit

> mammalian protein found in Mus musculus

**Wikidata**: [Q21496151](https://www.wikidata.org/wiki/Q21496151)  
**Source**: https://4ort.xyz/entity/enhancer-of-zeste-2-polycomb-repressive-complex-2-subunit-q21496151


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q61188)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
5. [Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
6. [STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
7. [The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
8. [Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
9. [The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
10. [An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
11. [Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
12. [Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
13. [The polycomb group protein EZH2 is required for mammalian circadian clock function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
14. [Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
15. [Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
16. [Juxtaposed Polycomb complexes co-regulate vertebral identity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
17. [Jarid2 regulates mouse epidermal stem cell activation and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
18. [Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
19. [Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
20. [Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
21. [BRCA1 is a negative modulator of the PRC2 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
22. [Point Mutations in the WD40 Domain of Eed Block Its Interaction with Ezh2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
23. [Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
24. [Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
25. [Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
26. [The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
27. [Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
28. [Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
29. [The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61188&geneProductId=UniProtKB:Q61188)
30. [Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
31. [Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
32. [Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
33. [Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
34. [Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
35. [Epiblast stem cell-based system reveals reprogramming synergy of germline factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
36. [Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
37. [Interaction of Mouse Polycomb-Group (Pc-G) Proteins Enx1 and Enx2 with Eed: Indication for Separate Pc-G Complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
38. [UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
39. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61188&geneProductId=UniProtKB:Q61188)
40. [The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
41. [Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
42. [PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
43. [A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61188)
44. ensembl Release 106