# Enhancer of zeste 2 polycomb repressive complex 2 subunit

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21097530](https://www.wikidata.org/wiki/Q21097530)  
**Source**: https://4ort.xyz/entity/enhancer-of-zeste-2-polycomb-repressive-complex-2-subunit-q21097530


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3287735)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3414621)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q15910)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
7. [A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
8. [An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
9. [Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
10. [O-GlcNAcylation regulates EZH2 protein stability and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
11. [Corepressor Protein CDYL Functions as a Molecular Bridge between Polycomb Repressor Complex 2 and Repressive Chromatin Mark Trimethylated Histone Lysine 27](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
12. [The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
13. [Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
14. [Role of the polycomb repressive complex 2 in acute promyelocytic leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
15. [Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
16. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
17. [A Y2H-seq approach defines the human protein methyltransferase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
18. [Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
19. [The Polycomb group protein EZH2 directly controls DNA methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
20. [ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
21. [Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
22. [Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
23. [ATRX directs binding of PRC2 to Xist RNA and Polycomb targets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
24. [CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
25. [Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
26. [Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
27. [A High-Density Map for Navigating the Human Polycomb Complexome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
28. [The histone variant macroH2A is an epigenetic regulator of key developmental genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
29. [Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
30. [Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
31. [JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
32. [Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
33. [RETRACTED: Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
34. [N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
35. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
36. [Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
37. [Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
38. [Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
39. [Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
40. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15910&geneProductId=UniProtKB:Q15910)
41. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
42. [An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
43. [Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
44. [Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S.cerevisiae telomeres](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
45. [Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15910&geneProductId=UniProtKB:Q15910)
46. [The polycomb group protein EZH2 is required for mammalian circadian clock function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
47. [Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
48. [MYC stimulates EZH2 expression by repression of its negative regulator miR-26a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910)
49. Ensembl Release 99
50. UMLS 2023