# Endothelin 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28557082](https://www.wikidata.org/wiki/Q28557082)  
**Source**: https://4ort.xyz/entity/endothelin-1-q28557082


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P22388)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
5. [Effects of endothelin-1 on the membrane potential and slow waves in circular smooth muscle of rat gastric antrum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
6. [Augmented endothelin vasoconstriction in intermittent hypoxia-induced hypertension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
7. [Synthesis and receptor sites of endothelin-1 in the rat liver vasculature](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
8. [Mechanism of endothelin 1 production in the cochlea of rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
9. [Estradiol attenuates hypoxia-induced pulmonary endothelin-1 gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
10. [Endothelin-1 induces organ-specific histamine liberation and neutrophil granulocyte accumulation in the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
11. [NAADP-induced Ca(2+ signaling in response to endothelin is via the receptor subtype B and requires the integrity of lipid rafts/caveolae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
12. [Role of endothelin-1 in blood pressure regulation in a rat model of visceral obesity and hypertension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
13. [Calcitonin gene-related peptide selectively relaxes contractile responses to endothelin-1 in rat mesenteric resistance arteries](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
14. [Differential regulation of the lung endothelin system by urban particulate matter and ozone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
15. [Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
16. [MicroRNA-27a/b mediates endothelin-1-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
17. [Time course alteration of endothelin-1 gene expression in the heart during exercise and recovery from post-exercise periods in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
18. [Identification of Receptor Binding and Activation Sites in Endothelin-1 by Use of Site-Directed Mutagenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
19. [Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
20. [Human big-endothelin-1 and endothelin-1 release prostacyclin via the activation of ET1 receptors in the rat perfused lung](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
21. [Endothelin-1 as a central mediator of LPS-induced fever in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
22. [Identification of early response genes and pathway activated by androgens in the initial segment and caput regions of the regressed rat epididymis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
23. [Endothelin-1 inhibits apoptosis of pulmonary arterial smooth muscle in the neonatal rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
24. [Cloprostenol, a prostaglandin F(2alpha) analog, induces hypoxia in rat placenta: BOLD contrast MRI](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
25. [Endothelin-1 as a potential marker of melatonin's therapeutic effects in smoking-induced vasculopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
26. [Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
27. [Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
28. [Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
29. [Effect of YM598, a selective endothelin ETA receptor antagonist, on endothelin-1-induced bone formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
30. [Endothelin-A and -B receptors, superoxide, and Ca2+ signaling in afferent arterioles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
31. [Danshensu protects vascular endothelia in a rat model of hyperhomocysteinemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
32. [Leptin induces vascular smooth muscle cell hypertrophy through angiotensin II- and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
33. [Adrenomedullin in the rat testis. II: Its production, actions on inhibin secretion, regulation by follicle-stimulating hormone, and its interaction with endothelin 1 in the Sertoli cell](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
34. [Autocrine regulation of the endothelin-1 gene in rat endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
35. [Inhibition of vascular contraction by intracisternal administration of preproendothelin-1 mRNA antisense oligoDNA in a rat experimental vasospasm model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
36. [Contractile responses and myosin phosphorylation in reconstituted fibers of smooth muscle cells from the rat cerebral artery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
37. [Comparison of the pituitary effects of the mammalian endothelins: vasoactive intestinal contractor (endothelin-beta, rat endothelin-2) is a potent inhibitor of prolactin secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
38. [Local antinociception induced by endothelin-1 in the hairy skin of the rat's back](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
39. [Endothelin as an autocrine factor in the regulation of parathyroid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
40. [Preproendothelin-1 expression is negatively regulated by IFNγ during hepatic stellate cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
41. [The endothelin axis influences enteric glia cell functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
42. [Adrenomedullin in the rat testis. I: Its production, actions on testosterone secretion, regulation by human chorionic gonadotropin, and its interaction with endothelin 1 in the leydig cell](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
43. [Transcriptional Regulation of Pre-Pro-Endothelin-1 Gene by Glucocorticoids in Vascular Smooth Muscle Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
44. [Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
45. [Upregulation of endothelin-1 production by lysophosphatidic acid in rat aortic endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
46. [Hypoxia reduces endothelin production by rat alveolar type II cells in primary culture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
47. [Glucocorticoids increase preproendothelin-1 expression in rat aorta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
48. [Transforming growth factor-beta1 induces endothelin-1 in a bovine pulmonary artery endothelial cell line and rat lungs via cAMP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
49. [Glomerular epithelial cells produce endothelin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)
50. [Influence of salt loading on the cardiac and renal preproendothelin-1 mRNA expression in stroke-prone spontaneously hypertensive rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22388)