# Endothelial PAS domain protein 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21981067](https://www.wikidata.org/wiki/Q21981067)  
**Source**: https://4ort.xyz/entity/endothelial-pas-domain-protein-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P97481)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
5. [A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
6. [Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
7. [Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481)
9. [The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481)
10. [The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
11. [Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
12. [Structural integration in hypoxia-inducible factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
13. [A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
15. [Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481)
16. [Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481)
17. [Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
18. [Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
19. [Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
20. [Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
21. [HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
22. [The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
23. [Deletion of HIF-2α in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
24. [Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
25. [Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
26. [The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
27. [Endothelium-intrinsic requirement for Hif-2alpha during vascular development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
28. [Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
29. [Acute postnatal ablation of Hif-2alpha results in anemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
30. [Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481)
31. [Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481)
32. [PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
33. [The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
34. [Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481)
35. ensembl Release 106