# Endothelial PAS domain protein 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21105431](https://www.wikidata.org/wiki/Q21105431)  
**Source**: https://4ort.xyz/entity/endothelial-pas-domain-protein-1-q21105431


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q99814)
3. Q20641742
4. [Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
6. [Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99814&geneProductId=UniProtKB:Q99814)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99814&geneProductId=UniProtKB:Q99814)
8. [Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
9. [Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
10. [Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
11. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
12. [Fructose-1,6-bisphosphatase opposes renal carcinoma progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
13. [Allosteric inhibition of hypoxia inducible factor-2 with small molecules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
14. [HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
15. [The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
16. [The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
17. [CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
18. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
19. [An oxygen-regulated switch in the protein synthesis machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
20. [Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
21. [Artificial ligand binding within the HIF2  PAS-B domain of the HIF2 transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
22. [Novel interaction partners of Bardet-Biedl syndrome proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
23. [HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
24. [Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
25. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
27. [The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
28. [Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
29. [Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99814&geneProductId=UniProtKB:Q99814)
30. [The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99814&geneProductId=UniProtKB:Q99814)
31. [Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99814&geneProductId=UniProtKB:Q99814)
32. [Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
33. [Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99814)
34. Ensembl Release 99