# Endoplasmic reticulum to nucleus signaling 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115427](https://www.wikidata.org/wiki/Q21115427)  
**Source**: https://4ort.xyz/entity/endoplasmic-reticulum-to-nucleus-signaling-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O75460)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
5. [Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
6. [Structure and Intermolecular Interactions of the Luminal Dimerization Domain of Human IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460)
8. [A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
9. [HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
10. [Heat Shock Protein 90 Modulates the Unfolded Protein Response by Stabilizing IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
11. [PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
12. [Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
13. [BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
14. [USP14 inhibits ER-associated degradation via interaction with IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
15. [JAB1 participates in unfolded protein responses by association and dissociation with IRE1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
16. [A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1α Activation in Pancreatic β Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
17. [Yip1A, a Novel Host Factor for the Activation of the IRE1 Pathway of the Unfolded Protein Response during Brucella Infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
18. [Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
19. [Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
20. [Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
21. [Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen‐induced arthritis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
22. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
23. [Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460)
24. [A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460)
25. [Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460)
26. [BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460)
27. [XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
28. [A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460)
30. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
31. [Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
32. [Unconventional splicing ofXBP1mRNA occurs in the cytoplasm during the mammalian unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
33. [Ursolic acid induces ER stress response to activate ASK1–JNK signaling and induce apoptosis in human bladder cancer T24 cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460)
34. [Ursolic acid induces ER stress response to activate ASK1–JNK signaling and induce apoptosis in human bladder cancer T24 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
35. [The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
36. [Unconventional splicing ofXBP1mRNA occurs in the cytoplasm during the mammalian unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460)
37. [XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460)
38. [Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
39. [XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75460)
40. [A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75460&geneProductId=UniProtKB:O75460)
41. Ensembl Release 99