# Egl-9 family hypoxia-inducible factor 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28561024](https://www.wikidata.org/wiki/Q28561024)  
**Source**: https://4ort.xyz/entity/egl-9-family-hypoxia-inducible-factor-1-q28561024


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P59722)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722)
5. [Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722)
6. [Beta-cell alpha-ketoglutarate hydroxylases may acutely participate in insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722)
7. [Hypoxia-Inducible Factor Prolyl-Hydroxylase 2 Senses High-Salt Intake to Increase Hypoxia Inducible Factor 1α Levels in the Renal Medulla](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722)
8. [Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722)
9. [Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722)
10. [Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722)
11. [Activation of the prolyl‐hydroxylase oxygen‐sensing signal cascade leads to AMPK activation in cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722)
12. ensembl Release 104