# egl-9 family hypoxia inducible factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21110136](https://www.wikidata.org/wiki/Q21110136)  
**Source**: https://4ort.xyz/entity/egl-9-family-hypoxia-inducible-factor-1-q21110136


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL4297619)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3544988)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3646118)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2338329)
6. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9GZT9)
7. Q20641742
8. [Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
10. [The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
11. [SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
12. [Myeloid Translocation Gene-16 Co-Repressor Promotes Degradation of Hypoxia-Inducible Factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
13. [Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
14. [Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
15. [OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
16. [The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
17. [Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
18. [Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
19. [IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
20. [A conserved family of prolyl-4-hydroxylases that modify HIF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
21. [Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
22. [Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
23. [1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
24. [SM-20 is a novel 40-kd protein whose expression in the arterial wall is restricted to smooth muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
25. [Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZT9)
26. ensembl Release 96