# Early endosome antigen 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q14911544](https://www.wikidata.org/wiki/Q14911544)  
**Source**: https://4ort.xyz/entity/early-endosome-antigen-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8BL66)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
5. [Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
6. [Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
7. [Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
8. [Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
9. [Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
10. [App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
11. [Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
12. [Sh3tc2 deficiency affects neuregulin-1/ErbB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
13. [Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
14. [Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
15. [The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
16. [Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
17. [Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles ...](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
18. [Expression, Localization, and Biochemical Characterization of Nicotinamide Mononucleotide Adenylyltransferase 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
19. [Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
20. [Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
21. [Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive Hypercholesterolemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
22. [In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
23. [CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
24. [FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
25. [The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
26. [Deficiency of Sorting Nexin 27 (SNX27) Leads to Growth Retardation and Elevated Levels of N-Methyl-d-Aspartate Receptor 2C (NR2C)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
27. [Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
28. [Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
29. [Goofy Coordinates the Acuity of Olfactory Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
30. [Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
31. [Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
32. [Tetraspanin CD151 promotes cell migration by regulating integrin trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
33. [Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
34. [GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
35. [Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
36. [Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BL66)
37. ensembl Release 106