# E2F transcription factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5322375](https://www.wikidata.org/wiki/Q5322375)  
**Source**: https://4ort.xyz/entity/e2f-transcription-factor-1-q5322375


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q01094)
3. Q20641742
4. [E2F transcriptional activation requires TRRAP and GCN5 cofactors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01094&geneProductId=UniProtKB:Q01094)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01094&geneProductId=UniProtKB:Q01094)
6. [ASPP1 and ASPP2 are new transcriptional targets of E2F](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01094&geneProductId=UniProtKB:Q01094)
7. [Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01094&geneProductId=UniProtKB:Q01094)
8. [Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01094&geneProductId=UniProtKB:Q01094)
9. [Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01094&geneProductId=UniProtKB:Q01094)
10. [Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
11. [Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
12. [Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
13. [Mixed Lineage Leukemia 5 (MLL5) Protein Regulates Cell Cycle Progression and E2F1-responsive Gene Expression via Association with Host Cell Factor-1 (HCF-1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
14. [Regulation of E2F1 function by the nuclear corepressor KAP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
15. [PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
16. [E2F transcriptional activation requires TRRAP and GCN5 cofactors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
17. [Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
18. [The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
19. [The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
20. [PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
21. [DDB, a Putative DNA Repair Protein, Can Function as a Transcriptional Partner of E2F1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
22. [Regulation of TopBP1 oligomerization by Akt/PKB for cell survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
23. [Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
24. [Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
25. [p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
26. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
27. [Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
28. [MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
29. [Proapoptotic function of the retinoblastoma tumor suppressor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
30. [Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
31. [DNA-damage-responsive acetylation of pRb regulates binding to E2F-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
32. [Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
33. [E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
34. [A High-Density Map for Navigating the Human Polycomb Complexome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
35. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
36. [Multimolecular complex of Par-4 and E2F1 binding to Smac promoter contributes to glutamate-induced apoptosis in human- bone mesenchymal stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
37. [TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
38. [GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
39. [Arginine methylation controls growth regulation by E2F-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
40. [Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
41. [Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
42. [Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
43. [Retinoblastoma protein represses transcription by recruiting a histone deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
44. [Retinoblastoma protein recruits histone deacetylase to repress transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
45. [hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
46. [E2F-1 has dual roles depending on the cell cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
47. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01094)
48. [DNA-binding specificities of human transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01094&geneProductId=UniProtKB:Q01094)
49. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01094&geneProductId=UniProtKB:Q01094)
50. [Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01094&geneProductId=UniProtKB:Q01094)