Dual serine/threonine and tyrosine protein kinase
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Protein kinase-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family
additional property: PropertyValue
  property ID: P361
  value: Protein kinase domain, protein family
additional property: PropertyValue
  property ID: P527
  value: serine/threonine-protein kinase, active site
additional property: PropertyValue
  property ID: P527
  value: protein kinase, ATP binding site
additional property: PropertyValue
  property ID: P527
  value: serine-threonine/tyrosine-protein kinase, catalytic domain
additional property: PropertyValue
  property ID: P637
  value: NP_056190
additional property: PropertyValue
  property ID: P637
  value: NP_955749
additional property: PropertyValue
  property ID: P637
  value: XP_011507694
additional property: PropertyValue
  property ID: P680
  value: transferase activity
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: protein serine/threonine/tyrosine kinase activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: cell junction
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P682
  value: positive regulation of fibroblast growth factor receptor signaling pathway
additional property: PropertyValue
  property ID: P682
  value: positive regulation of kinase activity
additional property: PropertyValue
  property ID: P682
  value: peptidyl-tyrosine phosphorylation
additional property: PropertyValue
  property ID: P702
  value: DSTYK
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000356129
additional property: PropertyValue
  property ID: P705
  value: ENSP00000356130
additional property: PropertyValue
  property ID: P705
  value: ENSP00000478016
confidence:
  popularity graph score:
    score: 0.001
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 8
      unique citations norm: 0.003
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 8
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q6XUX3
    source count: 1
    confidence: 0.2
  P361:
    value: Q24726164
    source count: 1
    confidence: 0.2
    value label: Protein kinase-like domain superfamily
  P361:
    value: Q83137014
    source count: 1
    confidence: 0.2
    value label: Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family
  P361:
    value: Q83138186
    source count: 1
    confidence: 0.2
    value label: Protein kinase domain, protein family
  P361:
    value: Q95354221
    source count: 1
    confidence: 0.2
    value label: Protein kinase, ATP binding site, protein family
  P361:
    value: Q95353644
    source count: 1
    confidence: 0.2
    value label: Serine/threonine-protein kinase, active site, protein family
  P527:
    value: Q24787419
    source count: 1
    confidence: 0.2
    value label: serine/threonine-protein kinase, active site
  P527:
    value: Q24769051
    source count: 1
    confidence: 0.2
    value label: protein kinase, ATP binding site
  P527:
    value: Q24740842
    source count: 1
    confidence: 0.2
    value label: serine-threonine/tyrosine-protein kinase, catalytic domain
  P527:
    value: Q24768234
    source count: 1
    confidence: 0.2
    value label: protein kinase domain
  P637:
    value: NP_056190
    source count: 1
    confidence: 0.2
  P637:
    value: NP_955749
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011507694
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011507695
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011507696
    source count: 1
    confidence: 0.2
  P680:
    value: Q14840131
    source count: 1
    confidence: 0.2
    value label: transferase activity
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14331146
    source count: 1
    confidence: 0.2
    value label: protein serine/threonine/tyrosine kinase activity
  P680:
    value: Q14863338
    source count: 1
    confidence: 0.2
    value label: protein tyrosine kinase activity
  P680:
    value: Q14820641
    source count: 1
    confidence: 0.2
    value label: protein kinase activity
  P681:
    value: Q79899
    source count: 3
    confidence: 0.6
    value label: cytoplasm
  P681:
    value: Q189073
    source count: 1
    confidence: 0.2
    value label: cell junction

value: Q29548
source count: 1
confidence: 0.2
value label: plasma membrane

value: Q14864700
source count: 3
confidence: 0.6
value label: basolateral plasma membrane

value: Q14819446
source count: 3
confidence: 0.6
value label: apical plasma membrane

value: Q14902773
source count: 1
confidence: 0.2
value label: positive regulation of fibroblast growth factor receptor signaling pathway

value: Q14866059
source count: 1
confidence: 0.2
value label: positive regulation of kinase activity

value: Q14330986
source count: 1
confidence: 0.2
value label: peptidyl-tyrosine phosphorylation

value: Q7251493
source count: 1
confidence: 0.2
value label: protein phosphorylation

value: Q14862250
source count: 1
confidence: 0.2
value label: cellular response to fibroblast growth factor stimulus

value: Q18037683
source count: 1
confidence: 0.2
value label: DSTYK

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000356129
source count: 1
confidence: 0.2

value: ENSP00000356130
source count: 1
confidence: 0.2

value: ENSP00000478016
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-03-27

source: Mutations in DSTYK and dominant urinary tract malformations
stated in qid: Q24309178
retrieved: 2019-04-08

source: Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23.
stated in qid: Q29871431
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21130913
domain: protein
level: standard
html url: https://4ort.xyz/entity/dual-serine-threonine-and-tyrosine-protein-kinase
markdown url: https://4ort.xyz/entity/dual-serine-threonine-and-tyrosine-protein-kinase.md
facts url summary: https://4ort.xyz/entity/dual-serine-threonine-and-tyrosine-protein-kinase/facts.json
facts url standard: https://4ort.xyz/entity/dual-serine-threonine-and-tyrosine-protein-kinase/facts.json
facts url full: https://4ort.xyz/entity/dual-serine-threonine-and-tyrosine-protein-kinase/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T10:28:03.070125Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:47:25.717321+00:00Z