# doxorubicin

> chemical compound

**Wikidata**: [Q18936](https://www.wikidata.org/wiki/Q18936)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Doxorubicin)  
**Source**: https://4ort.xyz/entity/doxorubicin


## References

1. IUPHAR/BPS Guide to PHARMACOLOGY
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL53463)
3. doxorubicin. Global Substance Registration System
4. [CAS Common Chemistry](https://commonchemistry.cas.org/detail?cas_rn=23214-92-8)
5. doxorubicin. PubChem
6. ChEBI release 2020-09-01
7. Integrated Authority File
8. Doxorubicin. DrugBank. 2015
9. Gene Ontology release 2019-11-16
10. DOXORUBICIN. ChEMBL
11. doxorubicin. IUPHAR/BPS Guide to PHARMACOLOGY
12. 1D12. Protein Data Bank
13. 1I1E. Protein Data Bank
14. 4DX7. Protein Data Bank
15. 1P20. Protein Data Bank
16. 2DR6. Protein Data Bank
17. 4ZVM. Protein Data Bank
18. 151D. Protein Data Bank
19. 1DA9. Protein Data Bank
20. Freebase Data Dumps. 2013
21. Doxorubicin. ChemSpider
22. doxorubicin. ChEBI
23. ChEBI release 2019-10-02
24. Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase
25. Expression of doxorubicin-daunorubicin resistance genes in different anthracycline-producing mutants of Streptomyces peucetius
26. Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952.
27. A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin
28. Exploration of geosmin synthase from Streptomyces peucetius ATCC 27952 by deletion of doxorubicin biosynthetic gene cluster
29. Enhancement of doxorubicin production by expression of structural sugar biosynthesis and glycosyltransferase genes in Streptomyces peucetius.
30. Self-resistance mechanism in Streptomyces peucetius: overexpression of drrA, drrB and drrC for doxorubicin enhancement
31. Isolation and genetic manipulation of the antibiotic down-regulatory gene, wblA ortholog for doxorubicin-producing Streptomyces strain improvement
32. Superoxide dismutase (SOD) genes in Streptomyces peucetius: effects of SODs on secondary metabolites production.
33. Enhancing macrolide production in Streptomyces by coexpressing three heterologous genes
34. Exploration of two epimerase homologs in Streptomyces peucetius ATCC 27952.
35. The DrrAB Efflux System of Streptomyces peucetius Is a Multidrug Transporter of Broad Substrate Specificity
36. Switching antibiotics production on and off in actinomycetes by an IclR family transcriptional regulator from Streptomyces peucetius ATCC 27952.
37. One-Pot Combinatorial Biosynthesis of Glycosylated Anthracyclines by Cocultivation of Streptomyces Strains Producing Aglycones and Nucleotide Deoxysugars
38. Complete genome sequence of Streptomyces peucetius ATCC 27952, the producer of anticancer anthracyclines and diverse secondary metabolites
39. Implication of orphan histidine kinase (OhkAsp) in biosynthesis of doxorubicin and daunorubicin in Streptomyces peucetius ATCC 27952
40. Isolation and characterization of a gene from Streptomyces sp. strain C5 that confers the ability to convert daunomycin to doxorubicin on Streptomyces lividans TK24
41. Expression and characterization of DrrA and DrrB proteins of Streptomyces peucetius in Escherichia coli: DrrA is an ATP binding protein
42. Minimal Streptomyces sp. strain C5 daunorubicin polyketide biosynthesis genes required for aklanonic acid biosynthesis
43. Production of the antitumor drug epirubicin (4′-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius
44. The Streptomyces peucetius dpsY anddnrX Genes Govern Early and Late Steps of Daunorubicin and Doxorubicin Biosynthesis
45. Purification, properties, and characterization of recombinant Streptomyces sp. strain C5 DoxA, a cytochrome P-450 catalyzing multiple steps in doxorubicin biosynthesis
46. Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene
47. Glucose kinases from Streptomyces peucetius var. caesius.
48. NdgR, an IclR-like regulator involved in amino-acid-dependent growth, quorum sensing, and antibiotic production in Streptomyces coelicolor
49. Precursor for biosynthesis of sugar moiety of doxorubicin depends on rhamnose biosynthetic pathway in Streptomyces peucetius ATCC 27952.
50. Identification of the duplicated genes for S-adenosyl-l-methionine synthetase (metK1-sp and metK2-sp) in Streptomyces peucetius var. caesius ATCC 27952.