# Dopamine receptor D4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q308856](https://www.wikidata.org/wiki/Q308856)  
**Source**: https://4ort.xyz/entity/dopamine-receptor-d4


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1423)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1108)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL54)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL53)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200916)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200503)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1713)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1275)
11. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200469)
12. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P21917)
13. Q20641742
14. Freebase Data Dumps. 2013
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917)
16. [G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
17. [SH3 binding domains in the dopamine D4 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
18. [Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
19. [Dopamine D4 receptor oligomerization--contribution to receptor biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
21. [Dopamine D4 receptors elevated in schizophrenia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
22. [Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
23. [Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
24. [Multiple dopamine D4 receptor variants in the human population](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
25. [Palmitoylation of the carboxyl-terminal tail of dopamine D4 receptor is required for surface expression, endocytosis, and signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
26. [Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
28. [Palmitoylation of the carboxyl-terminal tail of dopamine D4 receptor is required for surface expression, endocytosis, and signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917)
29. [Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917)
30. [Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917)
31. [SH3 binding domains in the dopamine D4 receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917)
32. [Dopamine D4 receptors elevated in schizophrenia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917)
33. [D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
34. [DISC1 regulates primary cilia that display specific dopamine receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
35. [Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
36. [Olanzapine reduces craving for alcohol: a DRD4 VNTR polymorphism by pharmacotherapy interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
37. [Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
38. [Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
39. [Dopamine D4 receptor (DRD4) gene polymorphism is associated with attachment disorganization in infants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
40. [Association of DRD4 with attention problems in normal childhood development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
41. [Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917)
42. [Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917)
43. Ensembl Release 99
44. Identifiers.org
45. UMLS 2023