# Dopamine receptor D2

> mammalian protein found in Mus musculus

**Wikidata**: [Q15335226](https://www.wikidata.org/wiki/Q15335226)  
**Source**: https://4ort.xyz/entity/dopamine-receptor-d2-q15335226


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P61168)
4. Q20641742
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
7. [Antiproliferative Role of Dopamine: Loss of D2 Receptors Causes Hormonal Dysfunction and Pituitary Hyperplasia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
8. [The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
9. [Neuroprotective role of dopamine against hippocampal cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
10. [Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
11. [Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
12. [Postnatal ontogeny of dopamine D3 receptors in the mouse brain: autoradiographic evidence for a transient cortical expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
13. [Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
14. [Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
15. [Circling behavior exhibited by a transgenic insertional mutant](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
16. [The fourth transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
17. [Lesions of mouse striatum induced by 6-hydroxydopamine differentially alter the density, rate of synthesis, and level of gene expression of D1 and D2 dopamine receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
18. [Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
19. [G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168)
21. [Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
22. [Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
23. [Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
24. [Alternative splicing of the dopamine D2 receptor directs specificity of coupling to G-proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168)
25. [Neurons exhibiting dopamine D2 receptor immunoreactivity in the substantia nigra of the mutant weaver mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
26. [Altered dopamine release and uptake kinetics in mice lacking D2 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
27. [Dopamine synapse is a neuroligin-2–mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
28. [Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
29. [Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
30. [Hyperthermic and lethal effects of methamphetamine: roles of dopamine D1 and D2 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
31. [Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
32. [The role of dopamine receptors in regulating the size of axonal arbors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
33. [Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168)
34. [Motor dysfunction in type 5 adenylyl cyclase-null mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168)
35. [Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
36. [Disruption of the D2 dopamine receptor alters GH and IGF-I secretion and causes dwarfism in male mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
37. [Dopamine D2 receptor knock-out mice are insensitive to the hypolocomotor and hypothermic effects of dopamine D2/D3 receptor agonists](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
38. [Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
39. [Pituitary Lactotroph Hyperplasia and Chronic Hyperprolactinemia in Dopamine D2 Receptor-Deficient Mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
40. [Absence of dopaminergic control on melanotrophs leads to Cushing's-like syndrome in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
41. [Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
42. [Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
43. [The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
44. [Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
45. [Role of dopamine D1 and D2 receptors in CRF-induced disruption of sensorimotor gating](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
46. [Accumbal dopamine D2 receptors are important for sensorimotor gating in C3H mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
47. [Dopamine D2 receptor stimulation promotes the proliferation of neural progenitor cells in adult mouse hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
48. [Topographical evaluation of behavioural phenotype in a line of mice with targeted gene deletion of the D2 dopamine receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)
49. [Changes in extracellular dopamine induced by morphine and cocaine: crucial control by D2 receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61168&geneProductId=UniProtKB:P61168)
50. [Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61168)