# Dopamine receptor D1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21984178](https://www.wikidata.org/wiki/Q21984178)  
**Source**: https://4ort.xyz/entity/dopamine-receptor-d1-q21984178


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q61616)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
5. [Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
6. [Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
7. [Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
8. [VPS35 regulates cell surface recycling and signaling of dopamine receptor D1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
9. [D1-like dopaminergic activation of phosphoinositide hydrolysis is independent of D1A dopamine receptors: evidence from D1A knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
10. [Mutation of SLC35D3 Causes Metabolic Syndrome by Impairing Dopamine Signaling in Striatal D1 Neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
12. [Altered striatal function in a mutant mouse lacking D1A dopamine receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
13. [Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
14. [D1 receptors mediate dopamine action in the fetal suprachiasmatic nuclei: studies of mice with targeted deletion of the D1 dopamine receptor gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
15. [Low affinity binding of the classical D1 antagonist SCH23390 in rodent brain: potential interaction with A2A and D2-like receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
16. [Lesions of mouse striatum induced by 6-hydroxydopamine differentially alter the density, rate of synthesis, and level of gene expression of D1 and D2 dopamine receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
17. [Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
18. [Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
19. [Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
20. [Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
21. [Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
22. [Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
23. [G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
24. [Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
25. [D1 receptors mediate dopamine action in the fetal suprachiasmatic nuclei: studies of mice with targeted deletion of the D1 dopamine receptor gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
26. [Altered striatal function in a mutant mouse lacking D1A dopamine receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
27. [Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
28. [Low affinity binding of the classical D1 antagonist SCH23390 in rodent brain: potential interaction with A2A and D2-like receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
29. [Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
30. [Lesions of mouse striatum induced by 6-hydroxydopamine differentially alter the density, rate of synthesis, and level of gene expression of D1 and D2 dopamine receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
31. [Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
32. [Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
33. [Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
34. [Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
35. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
36. [Mutation of SLC35D3 Causes Metabolic Syndrome by Impairing Dopamine Signaling in Striatal D1 Neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
37. [Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
38. [Dopamine synapse is a neuroligin-2–mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
39. [A critical time window for dopamine actions on the structural plasticity of dendritic spines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
40. [Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
41. [Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
42. [A phosphatase cascade by which rewarding stimuli control nucleosomal response](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61616&geneProductId=UniProtKB:Q61616)
43. [Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
44. [Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
45. [Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
46. [Hyperthermic and lethal effects of methamphetamine: roles of dopamine D1 and D2 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
47. [Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
48. [Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
49. [The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)
50. [Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61616)