# DNA topoisomerase II alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21108482](https://www.wikidata.org/wiki/Q21108482)  
**Source**: https://4ort.xyz/entity/dna-topoisomerase-ii-alpha-q21108482


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1117)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL68117)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL53463)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2107818)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL58)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL359744)
9. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P11388)
10. Q20641742
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
12. [Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
13. [The ATP-operated clamp of human DNA topoisomerase IIalpha: hyperstimulation of ATPase by "piggy-back" binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
14. [Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
15. [Using a biochemical approach to identify the primary dimerization regions in human DNA topoisomerase IIalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
16. [Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
17. [Histone deacetylase interacts directly with DNA topoisomerase II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
18. [BRCA1 participates in DNA decatenation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
19. [Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
20. [Metnase promotes restart and repair of stalled and collapsed replication forks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
21. [Metnase mediates resistance to topoisomerase II inhibitors in breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
22. [GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
23. [RNA helicase A interacts with dsDNA and topoisomerase IIalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
24. [The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
25. [Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
26. [BAF complexes facilitate decatenation of DNA by topoisomerase IIα](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
27. [Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
28. [Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
29. [DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
30. [DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
31. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388)
32. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
33. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388)
34. [Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388)
35. [Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilon](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388)
36. [DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388)
37. [A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11388&geneProductId=UniProtKB:P11388)
38. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
39. [A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
40. [Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
41. [DNA ligation catalyzed by human topoisomerase II alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11388)
42. Ensembl Release 99
43. UMLS 2023