# DNA topoisomerase I

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130471](https://www.wikidata.org/wiki/Q21130471)  
**Source**: https://4ort.xyz/entity/dna-topoisomerase-i


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL837)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL412309)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL435191)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P11387)
6. Q20641742
7. [Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
8. [Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
9. [Biochemical and biophysical analyses of recombinant forms of human topoisomerase I](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
10. [Identification of a nucleolin binding site in human topoisomerase I](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
11. [The domain organization of human topoisomerase I](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
12. [Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
14. [The Role of Lysine 532 in the Catalytic Mechanism of Human Topoisomerase I](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
15. [Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
17. [Rhythmic binding of Topoisomerase I impacts on the transcription of Bmal1 and circadian period](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
18. [BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
19. [Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
20. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
21. [Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
22. [Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
23. [NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
24. [Identification of a nucleolin binding site in human topoisomerase I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
25. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
26. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
27. [Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
28. [Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
29. [The domain organization of human topoisomerase I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
30. [Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
31. [Biochemical and biophysical analyses of recombinant forms of human topoisomerase I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
32. [Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
33. [Rhythmic binding of Topoisomerase I impacts on the transcription of Bmal1 and circadian period](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
34. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
35. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
36. [The Role of Lysine 532 in the Catalytic Mechanism of Human Topoisomerase I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
37. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
38. [Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
39. [Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
40. [A novel nuclear localization signal in human DNA topoisomerase I](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11387&geneProductId=UniProtKB:P11387)
41. [A novel nuclear localization signal in human DNA topoisomerase I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
42. [Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
43. [Topoisomerase II and tubulin inhibitors both induce the formation of apoptotic topoisomerase I cleavage complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
44. [RRM proteins interacting with the cap region of topoisomerase I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11387)
45. Ensembl Release 99
46. UMLS 2023