DNA topoisomerase 2 top-2 CELE_K12D12.1
type: Thing
description: protein found in Caenorhabditis elegans
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: It's Always Sunny in Philadelphia
additional property: PropertyValue
  property ID: P361
  value: Histidine kinase/HSP90-like ATPase superfamily
additional property: PropertyValue
  property ID: P361
  value: DNA topoisomerase, type IIA-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
additional property: PropertyValue
  property ID: P527
  value: DNA topoisomerase 2, TOPRIM domain
additional property: PropertyValue
  property ID: P527
  value: DNA topoisomerase, type IIA, subunit A/C-terminal
additional property: PropertyValue
  property ID: P527
  value: DNA topoisomerase, type IIA, subunit B, domain 2
additional property: PropertyValue
  property ID: P637
  value: NP_496536
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: DNA topoisomerase activity
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: chromosome
additional property: PropertyValue
  property ID: P682
  value: resolution of meiotic recombination intermediates
additional property: PropertyValue
  property ID: P682
  value: sister chromatid segregation
additional property: PropertyValue
  property ID: P682
  value: DNA metabolic process
additional property: PropertyValue
  property ID: P702
  value: top-2
additional property: PropertyValue
  property ID: P703
  value: Caenorhabditis elegans
additional property: PropertyValue
  property ID: P705
  value: K12D12.1
confidence:
  popularity graph score:
    score: 0.001
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 8
      unique citations norm: 0.003
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 8
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q23670
    source count: 1
    confidence: 0.2
    value label: It's Always Sunny in Philadelphia
  P361:
    value: Q41797986
    source count: 1
    confidence: 0.2
    value label: Histidine kinase/HSP90-like ATPase superfamily
  P361:
    value: Q24772226
    source count: 1
    confidence: 0.2
    value label: DNA topoisomerase, type IIA-like domain superfamily
  P361:
    value: Q24773428
    source count: 1
    confidence: 0.2
    value label: DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
  P361:
    value: Q24723191
    source count: 1
    confidence: 0.2
    value label: Ribosomal protein S5 domain 2-type fold
  P361:
    value: Q24787947
    source count: 1
    confidence: 0.2
    value label: DNA topoisomerase, type IIA, subunit B, C-terminal
  P527:
    value: Q28544190
    source count: 1
    confidence: 0.2
    value label: DNA topoisomerase 2, TOPRIM domain
  P527:
    value: Q24721556
    source count: 1
    confidence: 0.2
    value label: DNA topoisomerase, type IIA, subunit A/C-terminal
  P527:
    value: Q24780197
    source count: 1
    confidence: 0.2
    value label: DNA topoisomerase, type IIA, subunit B, domain 2
  P527:
    value: Q24780207
    source count: 1
    confidence: 0.2
    value label: Histidine kinase/HSP90-like ATPase domain
  P527:
    value: Q24768433
    source count: 1
    confidence: 0.2
    value label: C-terminal associated domain of TOPRIM
  P637:
    value: NP_496536
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14633858
    source count: 2
    confidence: 0.4
    value label: DNA binding
  P680:
    value: Q21112502
    source count: 1
    confidence: 0.2
    value label: DNA topoisomerase activity
  P680:
    value: Q22320802
    source count: 2
    confidence: 0.4
    value label: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
  P680:
    value: Q14817981
    source count: 2
    confidence: 0.4
    value label: ATP binding
  P681:
    value: Q40260
    source count: 2
    confidence: 0.4
    value label: nucleus
  P681:
    value: Q14817956
    source count: 1
    confidence: 0.2
    value label: nucleoplasm
  P681:
    value: Q37748
    source count: 1
    confidence: 0.2
    value label: chromosome
  P681:
    value: Q79899
    source count: 1
    confidence: 0.2
    value label: cytoplasm
  P681:
    value: Q918594
    source count: 1
    confidence: 0.2
    value label: spindle
  P682:
    value: Q14911700
    source count: 1
    confidence: 0.2
    value label: resolution of meiotic recombination intermediates

value: Q21108477
source count: 1
confidence: 0.2
value label: sister chromatid segregation

value: Q14877613
source count: 1
confidence: 0.2
value label: DNA metabolic process

value: Q14916134
source count: 1
confidence: 0.2
value label: DNA topological change

value: Q188941
source count: 1
confidence: 0.2
value label: cell cycle

value: Q29691223
source count: 1
confidence: 0.2
value label: top-2

value: Q91703
source count: 1
confidence: 0.2
value label: Caenorhabditis elegans

value: K12D12.1
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: A role for separase in the regulation of RAB-11-positive vesicles at the cleavage furrow and midbody
stated in qid: Q39432819
retrieved: 2019-04-08

source: LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
stated in qid: Q49789746
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2018-12-05

source: Q20641742
stated in qid: Q20641742
retrieved: 2018-12-14

source: ensembl Release 96
stated in qid: Q63170780

wikidata id: Q29803074
domain: protein
level: standard
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facts url summary: https://4ort.xyz/entity/dna-topoisomerase-2-top-2-cele-k12d12-1/facts.json
facts url standard: https://4ort.xyz/entity/dna-topoisomerase-2-top-2-cele-k12d12-1/facts.json
facts url full: https://4ort.xyz/entity/dna-topoisomerase-2-top-2-cele-k12d12-1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-03T13:34:11.145275Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:58:52.713056+00:00Z