# DNA polymerase alpha 1, catalytic subunit

> mammalian protein found in Homo sapiens

**Wikidata**: [Q19596944](https://www.wikidata.org/wiki/Q19596944)  
**Source**: https://4ort.xyz/entity/dna-polymerase-alpha-1-catalytic-subunit-q19596944


## References

1. UniProt
2. [BioGRID](https://thebiogrid.org/news/227)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL803)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1096882)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1637)
6. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P09884)
7. Q20641742
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
9. [Distinctive activities of DNA polymerases during human DNA replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
10. [Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
11. [Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
12. [MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
13. [Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
14. [Phosphorylated retinoblastoma protein stimulates DNA polymerase α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
15. [Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
16. [Direct interaction between cohesin complex and DNA replication machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
17. [Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
18. [Identification of domains of the HPV11 E1 protein required for DNA replication in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
19. [Interaction of herpes simplex virus 1 origin-binding protein with DNA polymerase alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
20. [Initiation of simian virus 40 DNA replication requires the interaction of a specific domain of human DNA polymerase alpha with large T antigen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
21. [Cloning, Mapping, Expression, Function, and Mutation Analyses of the Human Ortholog of the Hamster Putative Tumor Suppressor Gene doc-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
22. [Inhibition of DNA replication and DNA polymerase alpha activity by monoclonal anti-(DNA polymerase alpha) immunoglobulin G and F(ab) fragments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
23. [DNA polymerase-alpha. Purification and structural characterization of the near homogeneous enzyme from human KB cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
24. [Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
25. [Protein-nucleic acid interaction in reactions catalyzed with DNA polymerases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
27. [On the association of DNA polymerase alpha activity with the nuclear matrix in HeLa cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
28. [Ultrastructural aspects of the DNA polymerase alpha distribution during the cell cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
29. [Intracellular localization of human DNA polymerase alpha with monoclonal antibodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
30. [Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09884&geneProductId=UniProtKB:P09884)
31. [Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09884&geneProductId=UniProtKB:P09884)
32. [Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
33. [The role of DNA polymerase activity in human non-homologous end joining](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
34. [Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09884&geneProductId=UniProtKB:P09884)
35. [Monoclonal antibodies against human DNA polymerase-alpha inhibit DNA replication in permeabilized human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
36. [DNA repair synthesis in human fibroblasts requires DNA polymerase delta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
37. [A role for the human single-stranded DNA binding protein HSSB/RPA in an early stage of nucleotide excision repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
38. [The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
39. [Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09884)
40. Ensembl Release 99