# DNA methyltransferase 3 alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q22680017](https://www.wikidata.org/wiki/Q22680017)  
**Source**: https://4ort.xyz/entity/dna-methyltransferase-3-alpha-q22680017


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1201129)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Y6K1)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
6. [A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
7. [Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
8. [Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
9. [Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
10. [Structural insight into autoinhibition and histone H3-induced activation of DNMT3A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
11. [Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
12. [The Polycomb group protein EZH2 directly controls DNA methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
13. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
14. [The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
15. [Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
16. [cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
17. [PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
18. [The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
19. [Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
20. [Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
21. [Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K1)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6K1&geneProductId=UniProtKB:Q9Y6K1)
23. Ensembl Release 99