# DNA methyltransferase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5205796](https://www.wikidata.org/wiki/Q5205796)  
**Source**: https://4ort.xyz/entity/dna-methyltransferase-1


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1201129)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P26358)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358)
7. [CXXC domain of human DNMT1 is essential for enzymatic activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358)
8. [A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
9. [CXXC domain of human DNMT1 is essential for enzymatic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
10. [SUMOylation enhances DNA methyltransferase 1 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
11. [UHRF1 plays a role in maintaining DNA methylation in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
12. [The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
13. [Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
14. [The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
15. [RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
16. [Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
17. [SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
18. [Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
19. [The Polycomb group protein EZH2 directly controls DNA methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
20. [Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
21. [Global Mapping of Herpesvirus-Host Protein Complexes Reveals a Transcription Strategy for Late Genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
22. [A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
23. [Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
24. [A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
25. [New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358)
26. [The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
28. [New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
29. [Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P26358&geneProductId=UniProtKB:P26358)
30. [Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
31. [DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
32. [DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
33. [miR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26358)
34. Ensembl Release 99
35. UMLS 2023