# DNA ligase 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116593](https://www.wikidata.org/wiki/Q21116593)  
**Source**: https://4ort.xyz/entity/dna-ligase-4


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49917)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
5. [In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
6. [DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
7. [XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
8. [Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
9. [Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
10. [A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
11. [XLF regulates filament architecture of the XRCC4·ligase IV complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
12. [Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
13. [Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
14. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
15. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
16. [APLF promotes the assembly and activity of non-homologous end joining protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
17. [Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
18. [Crystal structure of an Xrcc4-DNA ligase IV complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
19. [Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
20. [DNA ligase IV from HeLa cell nuclei](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
21. [A High-Throughput Scintillation Proximity-Based Assay for Human DNA Ligase IV](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
22. [Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
23. [DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49917&geneProductId=UniProtKB:P49917)
24. [XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
25. [Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49917&geneProductId=UniProtKB:P49917)
27. [Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49917&geneProductId=UniProtKB:P49917)
28. [Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
30. [Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49917&geneProductId=UniProtKB:P49917)
31. [DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
32. [Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
33. [Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49917&geneProductId=UniProtKB:P49917)
34. [Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
35. [LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49917)
36. Ensembl Release 99