# DNA fragmentation factor subunit alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21101092](https://www.wikidata.org/wiki/Q21101092)  
**Source**: https://4ort.xyz/entity/dna-fragmentation-factor-subunit-alpha


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O00273)
3. Q20641742
4. [Identification of ICAD-derived peptides capable of inhibiting caspase-activated DNase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273)
5. [The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273)
6. [Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273)
7. [Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273)
8. [Fifty C-terminal amino acid residues are necessary for the chaperone activity of DFF45 but not for the inhibition of DFF40](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273)
9. [Fifty C-terminal amino acid residues are necessary for the chaperone activity of DFF45 but not for the inhibition of DFF40](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00273&geneProductId=UniProtKB:O00273)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273)
11. [DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273)
12. [Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273)
13. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00273&geneProductId=UniProtKB:O00273)
15. [Interaction of DNA fragmentation factor (DFF) with DNA reveals an unprecedented mechanism for nuclease inhibition and suggests that DFF can be activated in a DNA-bound state](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273)
16. [CIDE, a novel family of cell death activators with homology to the 45kDa subunit of the DNA fragmentation factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00273&geneProductId=UniProtKB:O00273)
17. [CIDE, a novel family of cell death activators with homology to the 45kDa subunit of the DNA fragmentation factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273)
18. Ensembl Release 99