# DNA damage inducible transcript 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116814](https://www.wikidata.org/wiki/Q21116814)  
**Source**: https://4ort.xyz/entity/dna-damage-inducible-transcript-3


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P35638)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
5. [C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
6. [Regulation of aldehyde reductase expression by STAF and CHOP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
7. [The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
8. [Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
9. [Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
10. [Source](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
11. [CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
12. [Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638)
13. [Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
14. [The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
15. [Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
16. [TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
17. [Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
18. [CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
19. [Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
20. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
21. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
22. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
23. [Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
24. [Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
25. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
26. [Roles of CHOP/GADD153 in endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
27. [Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
28. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
30. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638)
31. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638)
32. [Roles of CHOP/GADD153 in endoplasmic reticulum stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638)
33. [C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638)
34. [The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638)
35. [Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638)
36. [Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
37. [The endoplasmic reticulum stress response in aging and age-related diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
38. [Isolation, characterization and chromosomal localization of the human GADD153 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
39. [CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638)
40. [The endoplasmic reticulum stress response in aging and age-related diseases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638)
41. [CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638)
42. [Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35638&geneProductId=UniProtKB:P35638)
43. [Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
44. [Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
45. [Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35638)
46. Ensembl Release 99
47. UMLS 2023