# Dishevelled segment polarity protein 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q21981319](https://www.wikidata.org/wiki/Q21981319)  
**Source**: https://4ort.xyz/entity/dishevelled-segment-polarity-protein-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q60838)
3. Q20641742
4. [Tiam1 Regulates the Wnt/Dvl/Rac1 Signaling Pathway and the Differentiation of Midbrain Dopaminergic Neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
5. [Axin Contains Three Separable Domains That Confer Intramolecular, Homodimeric, and Heterodimeric Interactions Involved in Distinct Functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838)
7. [Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838)
8. [Molecular Basis of Wnt Activation via the DIX Domain Protein Ccd1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
9. [ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
10. [Nuclear Factor of Activated T Cells (NFAT) Proteins Repress Canonical Wnt Signaling via Its Interaction with Dishevelled (Dvl) Protein and Participate in Regulating Neural Progenitor Cell Proliferation and Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
11. [Dishevelled-2 docks and activates Src in a Wnt-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
12. [Dullard/Ctdnep1 Modulates WNT Signalling Activity for the Formation of Primordial Germ Cells in the Mouse Embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
13. [Structural Analysis of the Interaction between Dishevelled2 and Clathrin AP-2 Adaptor, A Critical Step in Noncanonical Wnt Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
14. [Identification of a novel Wnt5a–CK1ε–Dvl2–Plk1‐mediated primary cilia disassembly pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
15. [The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
16. [Diversin regulates heart formation and gastrulation movements in development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
17. [Independent Mutations in Mouse Vangl2 That Cause Neural Tube Defects in Looptail Mice Impair Interaction with Members of the Dishevelled Family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
18. [Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
19. [All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
20. [Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
21. [Mechanism of activation of the Formin protein Daam1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
22. [Regulation of the Wnt signaling pathway by disabled‐2 (Dab2)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
23. [Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
25. [The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
26. [Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
28. [KIF14 negatively regulates Rap1a–Radil signaling during breast cancer progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
29. [Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
30. [Inhibition of the Wnt/β-catenin pathway by the WWOX tumor suppressor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
31. [Dynamic recruitment of axin by Dishevelled protein assemblies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
32. [Disruption of the Dapper3 Gene Aggravates Ureteral Obstruction-mediated Renal Fibrosis by Amplifying Wnt/β-catenin Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
33. [Molecular Basis of Wnt Activation via the DIX Domain Protein Ccd1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838)
34. [Tiam1 Regulates the Wnt/Dvl/Rac1 Signaling Pathway and the Differentiation of Midbrain Dopaminergic Neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838)
35. [Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
36. [Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
37. [Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
38. [Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
39. [Sfrp Controls Apicobasal Polarity and Oriented Cell Division in Developing Gut Epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
40. [WNT-mediated relocalization of dishevelled proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
41. [Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
42. [Dimerization Choices Control the Ability of Axin and Dishevelled to Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
43. [Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
44. [Identification of a Wnt/Dvl/β-Catenin → Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
45. [WNT-mediated relocalization of dishevelled proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838)
46. [Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838)
47. [Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60838)
48. [Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838)
49. [Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838)
50. [Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60838&geneProductId=UniProtKB:Q60838)