# Discs large MAGUK scaffold protein 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21102524](https://www.wikidata.org/wiki/Q21102524)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/DLG4)  
**Source**: https://4ort.xyz/entity/discs-large-maguk-scaffold-protein-4


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P78352)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78352&geneProductId=UniProtKB:P78352)
6. [DGKι regulates presynaptic release during mGluR-dependent LTD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
7. [Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
8. [Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
9. [GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
10. [Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
11. [Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
12. [The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
13. [Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
14. [Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
15. [HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
16. [Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
17. [Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
18. [Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
19. [Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
20. [The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
21. [Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
22. [Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
23. [Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
25. [Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
26. [A functional role of postsynaptic density-95-guanylate kinase-associated protein complex in regulating Shank assembly and stability to synapses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
27. [Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
28. [Human Postsynaptic Density-95 (PSD95): Location of the Gene (DLG4) and Possible Function in Nonneural as Well as in Neural Tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
29. [Postsynaptic scaffolding molecules modulate the localization of neuroligins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78352&geneProductId=UniProtKB:P78352)
30. [Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
31. [Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
32. [Postsynaptic scaffolding molecules modulate the localization of neuroligins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78352)
33. ensembl Release 92
34. UMLS 2023
35. Transporter Classification database