# Discs large MAGUK scaffold protein 4

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28560166](https://www.wikidata.org/wiki/Q28560166)  
**Source**: https://4ort.xyz/entity/discs-large-maguk-scaffold-protein-4-q28560166


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P31016)
3. Q20641742
4. [SAP90 binds and clusters kainate receptors causing incomplete desensitization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
5. [A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
6. [Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
7. [Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
8. [Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
9. [Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
10. [Pursuit Auditory Tracking of Dichotically Presented Tonal Amplitudes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
11. [Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
12. [Interaction of LDL receptor-related protein 4 (LRP4) with postsynaptic scaffold proteins via its C-terminal PDZ domain-binding motif, and its regulation by Ca/calmodulin-dependent protein kinase II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
13. [BEGAIN (Brain-enriched Guanylate Kinase-associated Protein), a Novel Neuronal PSD-95/SAP90-binding Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
14. [Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
15. [Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
16. [Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
17. [Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
18. [Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
19. [MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
20. [Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
21. [Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
22. [Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
23. [Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
24. [Three isoforms of synaptic scaffolding molecule and their characterization. Multimerization between the isoforms and their interaction with N-methyl-D-aspartate receptors and SAP90/PSD-95-associated protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
25. [Palmitoylation-dependent CDKL5–PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
26. [Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
27. [Interaction of brain somatostatin receptors with the PDZ domains of PSD-95](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
28. [MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
29. [The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
30. [Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
31. [Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
32. [A novel family of adhesion-like molecules that interacts with the NMDA receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
33. [Vangl2, the planner cell polarity protein, is complexed with postsynaptic density protein PSD‐95](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
34. [Direct association of the unique C‐terminal tail of transmembrane AMPA receptor regulatory protein γ‐8 with calcineurin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
35. [SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
36. [Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
37. [PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
38. [Interaction between SAP97 and PSD-95, two Maguk proteins involved in synaptic trafficking of AMPA receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
39. [Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
40. [Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
41. [Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
42. [Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
43. [DGKι regulates presynaptic release during mGluR-dependent LTD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
44. [The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
45. [Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
46. [A Novel Multiple PDZ Domain-containing Molecule Interacting withN-Methyl-d-aspartateReceptors and Neuronal Cell Adhesion Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
47. [SPIN90/WISH interacts with PSD-95 and regulates dendritic spinogenesis via an N-WASP-independent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
48. [Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
49. [Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)
50. [Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31016)