# Discs large MAGUK scaffold protein 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21113813](https://www.wikidata.org/wiki/Q21113813)  
**Source**: https://4ort.xyz/entity/discs-large-maguk-scaffold-protein-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q12959)
3. Q20641742
4. [Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
5. [Large-scale characterization of HeLa cell nuclear phosphoproteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
6. [Different isoforms of synapse-associated protein, SAP97, are expressed in the heart and have distinct effects on the voltage-gated K+ channel Kv1.5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
7. [DLG1: chromosome location of the closest human homologue of the Drosophila discs large tumor suppressor gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
8. [Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
9. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
11. [Identification of mitogen‐activated protein/extracellular signal‐responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc‐large](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
12. [Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
13. [GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
14. [Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
15. [Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
16. [Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
17. [Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
18. [The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
19. [Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
20. [Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
21. [Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
22. [Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
23. [MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
24. [Proteome-wide analysis of phospho-regulated PDZ domain interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
25. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
26. [Association of cottontail rabbit papillomavirus E6 oncoproteins with the hDlg/SAP97 tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
27. [Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
28. [Solution structure of the hDlg/SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
29. [Identification of SAP97 as an intracellular binding partner of TACE](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
30. [The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
31. [The multiple-specificity landscape of modular peptide recognition domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
32. [Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
33. [Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
34. [Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
35. [Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
36. [Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
37. [Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
38. [Characterization of PDZ-binding kinase, a mitotic kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
39. [Human Homologue of the Drosophila Discs Large Tumor Suppressor Binds to p56 Tyrosine Kinase and Shaker Type Kv1.3 Potassium Channel in T Lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
40. [The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
41. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959)
42. [Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
43. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959)
44. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
45. [Identification of mitogen‐activated protein/extracellular signal‐responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc‐large](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959)
46. [The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959)
47. [The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
48. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959)
49. [SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12959)
50. [Myo6 facilitates the translocation of endocytic vesicles from cell peripheries](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q12959)