# Disabled 2, mitogen-responsive phosphoprotein

> mammalian protein found in Mus musculus

**Wikidata**: [Q21982744](https://www.wikidata.org/wiki/Q21982744)  
**Source**: https://4ort.xyz/entity/disabled-2-mitogen-responsive-phosphoprotein


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P98078)
3. Q20641742
4. [Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
6. [The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
7. [Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
8. [Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
9. [Regulation of the Wnt signaling pathway by disabled-2 (Dab2)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
10. [Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
11. [The NECAP PHear domain increases clathrin accessory protein binding potential](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
12. [Dab2 links CIN85 with clathrin-mediated receptor internalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
13. [Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
14. [FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
15. [The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
16. [Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
17. [p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
18. [Cloning and characterization of mouse disabled 2 interacting protein 2, a mouse orthologue of human NOSTRIN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
19. [Spatial regulation of VEGF receptor endocytosis in angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
20. [Crystal structures of the Dab homology domains of mouse disabled 1 and 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
21. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98078&geneProductId=UniProtKB:P98078)
22. [p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98078&geneProductId=UniProtKB:P98078)
23. [Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
24. [The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
25. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
26. [Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
27. [Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
28. [Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98078&geneProductId=UniProtKB:P98078)
29. [Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
30. [Type II Transforming Growth Factor-β Receptor Recycling Is Dependent upon the Clathrin Adaptor Protein Dab2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
31. [Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
32. [Quantitative proteomics identifies a Dab2/integrin module regulating cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078)
33. [Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98078&geneProductId=UniProtKB:P98078)
34. ensembl Release 106