# Dipeptidyl peptidase 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q412214](https://www.wikidata.org/wiki/Q412214)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Dipeptidyl_peptidase-4)  
**Source**: https://4ort.xyz/entity/dipeptidyl-peptidase-4


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2147777)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1929396)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1650443)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2105762)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1779710)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL515387)
9. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P27487)
10. Q20641742
11. Freebase Data Dumps. 2013
12. [3D structure of the CD26-ADA complex obtained by cryo-EM and single particle analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
13. [Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
14. [The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
15. [The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
16. [Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
17. [Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
18. [Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
20. [Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
21. [One site mutation disrupts dimer formation in human DPP-IV proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
22. [Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
23. [Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
24. [Direct association of adenosine deaminase with a T cell activation antigen, CD26](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
25. [Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
26. [Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
27. [Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
28. [Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
29. [Investigation of glucose-dependent insulinotropic polypeptide-(1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. A novel [...]](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
30. [Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
31. [Intestinal epithelial cells secrete exosome-like vesicles](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27487&geneProductId=UniProtKB:P27487)
32. [Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27487&geneProductId=UniProtKB:P27487)
33. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27487&geneProductId=UniProtKB:P27487)
34. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27487&geneProductId=UniProtKB:P27487)
35. [Protein profile of exosomes from trabecular meshwork cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27487&geneProductId=UniProtKB:P27487)
36. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27487&geneProductId=UniProtKB:P27487)
37. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27487&geneProductId=UniProtKB:P27487)
38. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27487&geneProductId=UniProtKB:P27487)
39. [Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
40. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27487&geneProductId=UniProtKB:P27487)
41. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27487&geneProductId=UniProtKB:P27487)
42. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27487&geneProductId=UniProtKB:P27487)
43. [Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
44. [Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
45. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
46. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
47. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
48. [Protein profile of exosomes from trabecular meshwork cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
49. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)
50. [Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27487)