# dihydrofolate reductase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q417149](https://www.wikidata.org/wiki/Q417149)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Dihydrofolate_reductase)  
**Source**: https://4ort.xyz/entity/dihydrofolate-reductase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL7492)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P00374)
5. Q20641742
6. Freebase Data Dumps. 2013
7. [Unusual transient- and steady-state kinetic behavior is predicted by the kinetic scheme operational for recombinant human dihydrofolate reductase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00374)
8. [The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00374&geneProductId=UniProtKB:P00374)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00374&geneProductId=UniProtKB:P00374)
10. [The former annotated human pseudogene dihydrofolate reductase-like 1 ( DHFRL1 ) is expressed and functional](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00374&geneProductId=UniProtKB:P00374)
11. [Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00374&geneProductId=UniProtKB:P00374)
12. [Unusual transient- and steady-state kinetic behavior is predicted by the kinetic scheme operational for recombinant human dihydrofolate reductase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00374&geneProductId=UniProtKB:P00374)
13. [Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P00374&geneProductId=UniProtKB:P00374)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00374)
15. [The former annotated human pseudogene dihydrofolate reductase-like 1 ( DHFRL1 ) is expressed and functional](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00374)
16. [Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00374)
17. [The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00374)
18. [Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00374)
19. [Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00374)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00374)
21. Ensembl Release 99
22. Identifiers.org
23. Quora
24. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)