# Dihydrofolate reductase

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28562776](https://www.wikidata.org/wiki/Q28562776)  
**Source**: https://4ort.xyz/entity/dihydrofolate-reductase-q28562776


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q920D2)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920D2)
5. [Transport, binding, and polyglutamation of methotrexate in freshly isolated rat hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920D2)
6. [An active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920D2)
7. [Isolation of rat dihydrofolate reductase gene and characterization of recombinant enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920D2)
8. [Comparative activity of rat liver dihydrofolate reductase with 7,8-dihydrofolate and other 7,8-dihydropteridines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920D2)
9. [Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920D2)
10. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920D2)
11. [Persistent nicotine treatment potentiates amplification of the dihydrofolate reductase gene in rat lung epithelial cells as a consequence of Ras activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q920D2)
12. ensembl Release 106