# Dicer 1, ribonuclease III

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111297](https://www.wikidata.org/wiki/Q21111297)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Dicer)  
**Source**: https://4ort.xyz/entity/dicer-1-ribonuclease-iii


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9UPY3)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
5. [Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
6. [Autoinhibition of human dicer by its internal helicase domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
7. [In vitro reconstitution of the human RISC-loading complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
8. [Structure of precursor microRNA’s terminal loop regulates human Dicer’s dicing activity by switching DExH/D domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
9. [Structural insights into RNA processing by the human RISC-loading complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
10. [An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
11. [HCV core protein interacts with Dicer to antagonize RNA silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
12. [Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
13. [Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
14. [MicroRNA silencing through RISC recruitment of eIF6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
15. [RNA helicase A interacts with RISC in human cells and functions in RISC loading](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
16. [TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
17. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
18. [The role of PACT in the RNA silencing pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
19. [TWEAK Negatively Regulates Human Dicer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
20. [Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
21. [Interaction of human T‐cell lymphotropic virus type I Rex protein with Dicer suppresses RNAi silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
22. [Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference–mediated silencing in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
23. [ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
24. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
25. [Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
26. [Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
27. [Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
28. [Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
29. [TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
30. [Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
31. [Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
32. [Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
33. [Ribonuclease activity and RNA binding of recombinant human Dicer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
34. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3)
35. [Dicer recognizes the 5' end of RNA for efficient and accurate processing](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3)
36. [Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3)
37. [Role for a bidentate ribonuclease in the initiation step of RNA interference](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3)
38. [A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3)
39. [Ribonuclease activity and RNA binding of recombinant human Dicer](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3)
40. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
41. [Dicer recognizes the 5' end of RNA for efficient and accurate processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
42. [Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
43. [A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
44. [Role for a bidentate ribonuclease in the initiation step of RNA interference](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
45. [A human, ATP-independent, RISC assembly machine fueled by pre-miRNA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3)
46. [A human, ATP-independent, RISC assembly machine fueled by pre-miRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
47. [Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3)
48. [TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3)
49. [Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3)
50. [In vitro reconstitution of the human RISC-loading complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3)