DExH-box helicase 58
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: P-loop containing nucleoside triphosphate hydrolase
additional property: PropertyValue
  property ID: P361
  value: RIG-I-like receptor, C-terminal domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Helicase superfamily 1/2, ATP-binding domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Helicase/UvrB, N-terminal
additional property: PropertyValue
  property ID: P527
  value: RIG-I-like receptor, C-terminal regulatory domain
additional property: PropertyValue
  property ID: P527
  value: Helicase, C-terminal
additional property: PropertyValue
  property ID: P637
  value: NP_077024
additional property: PropertyValue
  property ID: P637
  value: XP_016880548
additional property: PropertyValue
  property ID: P638
  value: 2RQA
additional property: PropertyValue
  property ID: P638
  value: 2W4R
additional property: PropertyValue
  property ID: P638
  value: 3EQT
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: helicase activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P682
  value: negative regulation of MDA-5 signaling pathway
additional property: PropertyValue
  property ID: P682
  value: regulation of innate immune response
additional property: PropertyValue
  property ID: P682
  value: immune system process
additional property: PropertyValue
  property ID: P702
  value: DHX58
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000251642
additional property: PropertyValue
  property ID: P705
  value: ENSP00000404639
additional property: PropertyValue
  property ID: P705
  value: ENSP00000416389
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 14
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 14
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q96C10
    source count: 1
    confidence: 0.2
  P361:
    value: Q24726930
    source count: 1
    confidence: 0.2
    value label: P-loop containing nucleoside triphosphate hydrolase
  P361:
    value: Q54444497
    source count: 1
    confidence: 0.2
    value label: RIG-I-like receptor, C-terminal domain superfamily
  P361:
    value: Q83133257
    source count: 1
    confidence: 0.2
    value label: Helicase superfamily 1/2, ATP-binding domain, protein family
  P361:
    value: Q83165958
    source count: 1
    confidence: 0.2
    value label: Helicase, C-terminal domain, protein family
  P361:
    value: Q83138939
    source count: 1
    confidence: 0.2
    value label: Helicase/UvrB, N-terminal domain, protein family
  P527:
    value: Q24767018
    source count: 1
    confidence: 0.2
    value label: Helicase/UvrB, N-terminal
  P527:
    value: Q24722825
    source count: 1
    confidence: 0.2
    value label: RIG-I-like receptor, C-terminal regulatory domain
  P527:
    value: Q24786718
    source count: 1
    confidence: 0.2
    value label: Helicase, C-terminal
  P527:
    value: Q24721420
    source count: 1
    confidence: 0.2
    value label: Helicase superfamily 1/2, ATP-binding domain
  P637:
    value: NP_077024
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016880548
    source count: 1
    confidence: 0.2
  P638:
    value: 2RQA
    source count: 1
    confidence: 0.2
  P638:
    value: 2W4R
    source count: 1
    confidence: 0.2
  P638:
    value: 3EQT
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633858
    source count: 1
    confidence: 0.2
    value label: DNA binding
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14875014
    source count: 1
    confidence: 0.2
    value label: helicase activity
  P680:
    value: Q14633865
    source count: 1
    confidence: 0.2
    value label: zinc ion binding
  P680:
    value: Q13667380
    source count: 1
    confidence: 0.2
    value label: metal ion binding
  P681:
    value: Q79899
    source count: 2
    confidence: 0.4
    value label: cytoplasm
  P682:
    value: Q21110440
    source count: 1
    confidence: 0.2
    value label: negative regulation of MDA-5 signaling pathway

value: Q14913302
source count: 1
confidence: 0.2
value label: regulation of innate immune response

value: Q14916317
source count: 1
confidence: 0.2
value label: immune system process

value: Q14864931
source count: 2
confidence: 0.4
value label: response to virus

value: Q21101074
source count: 2
confidence: 0.4
value label: positive regulation of RIG-I signaling pathway

value: Q18046012
source count: 1
confidence: 0.2
value label: DHX58

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000251642
source count: 1
confidence: 0.2

value: ENSP00000404639
source count: 1
confidence: 0.2

value: ENSP00000416389
source count: 1
confidence: 0.2

value: ENSP00000466721
source count: 1
confidence: 0.2

value: ENSP00000467470
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-01

source: The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
stated in qid: Q24320147
retrieved: 2018-01-01

source: DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling
stated in qid: Q24317028
retrieved: 2018-01-01

source: A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection
stated in qid: Q24306232
retrieved: 2018-01-01

source: Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
stated in qid: Q24338327
retrieved: 2018-01-01

source: Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
stated in qid: Q24337463
retrieved: 2018-01-01

source: A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2
stated in qid: Q24320094
retrieved: 2018-01-01

source: Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response
stated in qid: Q24321366
retrieved: 2018-01-01

source: RIG-I/MDA5/MAVS Are Required To Signal a Protective IFN Response in Rotavirus-Infected Intestinal Epithelium
stated in qid: Q24321688
retrieved: 2018-01-01

source: Ambivalent role of the innate immune response in rabies virus pathogenesis
stated in qid: Q24300579
retrieved: 2018-01-01

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21111268
domain: protein
level: standard
html url: https://4ort.xyz/entity/dexh-box-helicase-58
markdown url: https://4ort.xyz/entity/dexh-box-helicase-58.md
facts url summary: https://4ort.xyz/entity/dexh-box-helicase-58/facts.json
facts url standard: https://4ort.xyz/entity/dexh-box-helicase-58/facts.json
facts url full: https://4ort.xyz/entity/dexh-box-helicase-58/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-28T12:51:53.543261Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:58:50.900290+00:00Z