# DExD/H-box helicase 58

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21100537](https://www.wikidata.org/wiki/Q21100537)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/RIG-I)  
**Source**: https://4ort.xyz/entity/dexd-h-box-helicase-58


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O95786)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
5. [The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
6. [DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
7. [Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
8. [NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
9. [The nucleolar protein GLTSCR2 is required for efficient viral replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
10. [Negative Regulation of RIG-I-Mediated Innate Antiviral Signaling by SEC14L1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
11. [Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
12. [The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
13. [SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
14. [The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
15. [Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
16. [Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
17. [The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
18. [IFN-Induced TPR Protein IFIT3 Potentiates Antiviral Signaling by Bridging MAVS and TBK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
19. [STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
20. [Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
21. [Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
22. [Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
23. [Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
24. [Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
25. [Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
26. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
27. [Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
28. [DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
29. [Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
30. [Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
31. [Toscana virus NSs protein inhibits the induction of type I interferon by interacting with RIG-I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
32. [Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
33. [Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
34. [ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
35. [Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
36. [IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
37. [Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
38. [Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
39. [A non-canonical role of the p97 complex in RIG-I antiviral signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
40. [Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
41. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O95786&geneProductId=UniProtKB:O95786)
42. [RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
43. [Immune signaling by RIG-I-like receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
44. [TLR9 and RIG-I signaling in human endocervical epithelial cells modulates inflammatory responses of macrophages and dendritic cells in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
45. [RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
46. [DHX9 Pairs with IPS-1 To Sense Double-Stranded RNA in Myeloid Dendritic Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95786)
47. Ensembl Release 99
48. UMLS 2023
49. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)